BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways
J Wen, X Liu, Y Qi, F Niu, Z Niu, W Geng, Z Zou… - Journal of Experimental …, 2019 - Springer
Background BMP3 gene is often found hypermethylated and hence inactivated in several
types of cancers including colorectal cancer (CRC), indicating that it has a suppressor role in …
types of cancers including colorectal cancer (CRC), indicating that it has a suppressor role in …
Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells
R Vishnubalaji, S Yue, M Alfayez, M Kassem… - Cancer cell …, 2016 - Springer
Background Molecular profiling of colorectal cancer (CRC) based on global gene
expression has revealed multiple dysregulated signalling pathways associated with drug …
expression has revealed multiple dysregulated signalling pathways associated with drug …
Alteration of tumor suppressor BMP5 in sporadic colorectal cancer: a genomic and transcriptomic profiling based study
E Chen, F Yang, H He, Q Li, W Zhang, J Xing, Z Zhu… - Molecular cancer, 2018 - Springer
Background Although the genetic spectrum of human colorectal cancer (CRC) is mainly
characterized by APC, KRAS and TP53 mutations, driver genes in tumor initiation have not …
characterized by APC, KRAS and TP53 mutations, driver genes in tumor initiation have not …
Autocrine BMP-4 signaling is a therapeutic target in colorectal cancer
Y Yokoyama, T Watanabe, Y Tamura, Y Hashizume… - Cancer research, 2017 - AACR
Poor prognoses for colorectal cancer patients with metastatic lesions have driven demand
for the development of novel targeted therapies. Here, we demonstrate that expression of …
for the development of novel targeted therapies. Here, we demonstrate that expression of …
Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells
Y Zhang, X Chen, M Qiao, BQ Zhang… - Oncology …, 2014 - spandidos-publications.com
Colorectal cancer (CRC) is one of the most deadly cancers worldwide. Significant progress
has been made in understanding the molecular pathogenesis of CRC, which has led to …
has been made in understanding the molecular pathogenesis of CRC, which has led to …
BMP10 suppresses hepatocellular carcinoma progression via PTPRS–STAT3 axis
YM Yuan, N Ma, EB Zhang, TW Chen, H Jiang, FF Yin… - Oncogene, 2019 - nature.com
Abstract Bone morphogenetic protein 10 (BMP10), one member of the BMP family, is
involved in various development events. Dysregulation of BMP10 has been observed in …
involved in various development events. Dysregulation of BMP10 has been observed in …
BMP‑9 is a novel marker for colorectal tumorigenesis undergoing the normal mucosa‑adenoma‑adenocarcinoma sequence and is associated with colorectal cancer …
Y Fan, L Guo, H Zheng, C Ji, W Wang… - Oncology …, 2020 - spandidos-publications.com
Depending on the type of cancer, bone morphogenetic protein‑9 (BMP‑9) can promote or
inhibit tumorigenesis; however, the function of BMP‑9 in colorectal cancer remains unclear …
inhibit tumorigenesis; however, the function of BMP‑9 in colorectal cancer remains unclear …
High levels of BMP2 promote liver cancer growth via the activation of myeloid-derived suppressor cells
Bone morphogenetic protein 2 (BMP2) signaling had significant roles in diverse pathological
processes, such as cancer. Nevertheless, the interaction between BMP2 and carcinoma …
processes, such as cancer. Nevertheless, the interaction between BMP2 and carcinoma …
BMP4 promotes the metastasis of gastric cancer by inducing epithelial–mesenchymal transition via ID1
G Deng, Y Chen, C Guo, L Yin, Y Han… - Journal of cell …, 2020 - journals.biologists.com
Epithelial–mesenchymal transition (EMT) is a crucial process for cancer cells to acquire
metastatic potential, which primarily causes death in gastric cancer (GC) patients. Bone …
metastatic potential, which primarily causes death in gastric cancer (GC) patients. Bone …
[HTML][HTML] Methylated bone morphogenetic protein 3 (BMP3) gene: evaluation of tumor suppressor function and biomarker potential in biliary cancer
JB Kisiel, J Li, H Zou, AM Oseini… - Journal of molecular …, 2013 - ncbi.nlm.nih.gov
Background Although cholangiocarcinoma (CC) is an uncommon and highly lethal
malignancy, early detection enables the application of potentially curative therapies and …
malignancy, early detection enables the application of potentially curative therapies and …