Background BMP3 gene is often found hypermethylated and hence inactivated in several
types of cancers including colorectal cancer (CRC), indicating that it has a suppressor role in …

Background Molecular profiling of colorectal cancer (CRC) based on global gene
expression has revealed multiple dysregulated signalling pathways associated with drug …

Background Although the genetic spectrum of human colorectal cancer (CRC) is mainly
characterized by APC, KRAS and TP53 mutations, driver genes in tumor initiation have not …

Poor prognoses for colorectal cancer patients with metastatic lesions have driven demand
for the development of novel targeted therapies. Here, we demonstrate that expression of …

Colorectal cancer (CRC) is one of the most deadly cancers worldwide. Significant progress
has been made in understanding the molecular pathogenesis of CRC, which has led to …

Abstract Bone morphogenetic protein 10 (BMP10), one member of the BMP family, is
involved in various development events. Dysregulation of BMP10 has been observed in …

Depending on the type of cancer, bone morphogenetic protein‑9 (BMP‑9) can promote or
inhibit tumorigenesis; however, the function of BMP‑9 in colorectal cancer remains unclear …

Bone morphogenetic protein 2 (BMP2) signaling had significant roles in diverse pathological
processes, such as cancer. Nevertheless, the interaction between BMP2 and carcinoma …

Epithelial–mesenchymal transition (EMT) is a crucial process for cancer cells to acquire
metastatic potential, which primarily causes death in gastric cancer (GC) patients. Bone …

Background Although cholangiocarcinoma (CC) is an uncommon and highly lethal
malignancy, early detection enables the application of potentially curative therapies and …