Dihydrolipoic acid–gold nanoclusters regulate microglial polarization and have the potential to alter neurogenesis

L Xiao, F Wei, Y Zhou, GJ Anderson, DM Frazer… - Nano …, 2019 - ACS Publications
Microglia-mediated neuroinflammation is one of the most significant features in a variety of
central nervous system (CNS) disorders such as traumatic brain injury, stroke, and many …

Microglia polarization from M1 to M2 in neurodegenerative diseases

S Guo, H Wang, Y Yin - Frontiers in aging neuroscience, 2022 - frontiersin.org
Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases
such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis …

Microglia polarization in Alzheimer's disease: mechanisms and a potential therapeutic target

Q Wang, H Yao, W Liu, B Ya, H Cheng… - Frontiers in aging …, 2021 - frontiersin.org
Neuroinflammation regulated by microglia is one of the important factors involved in the
pathogenesis of Alzheimer's disease (AD). Activated microglia exhibited phenotypes termed …

Microglial polarization: novel therapeutic mechanism against Alzheimer's disease

K Yao, H Zu - Inflammopharmacology, 2020 - Springer
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease that results in
progressive dementia, and exhibits high disability and fatality rates. Recent evidence has …

Natural products as a potential modulator of microglial polarization in neurodegenerative diseases

X Jin, MY Liu, DF Zhang, X Zhong, K Du, P Qian… - Pharmacological …, 2019 - Elsevier
abstract Neurodegenerative diseases (NDs) are characterized by the progressive loss of
structure and function of neurons most common in elderly population, mainly including …

Nanoparticles: A Hope for the Treatment of Inflammation in CNS

FD Zhu, YJ Hu, L Yu, XG Zhou, JM Wu… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammation, an inflammatory response within the central nervous system (CNS), is a
main hallmark of common neurodegenerative diseases, including Alzheimer's disease (AD) …

Microglial response to gold nanoparticles

E Hutter, S Boridy, S Labrecque, M Lalancette-Hébert… - ACS …, 2010 - ACS Publications
Given the emergence of nanotherapeutics and nanodiagnostics as key tools in today's
medicine, it has become of critical importance to define precisely the interactions of …

L-DOPA functionalized, multi-branched gold nanoparticles as brain-targeted nano-vehicles

DA Gonzalez-Carter, ZY Ong, CM McGilvery… - … , Biology and Medicine, 2019 - Elsevier
The blood–brain barrier (BBB) is a protective endothelial barrier lining the brain
microvasculature which prevents brain delivery of therapies against brain diseases. Hence …

Role of microglia in neurological disorders and their potentials as a therapeutic target

L Du, Y Zhang, Y Chen, J Zhu, Y Yang… - Molecular neurobiology, 2017 - Springer
Microglia are resident macrophage-like immune cells in the central nervous system (CNS)
and play a vital role in both physiological and pathological conditions, including restoring …

Gold nanoclusters for Parkinson's disease treatment

G Gao, R Chen, M He, J Li, L Wang, T Sun - Biomaterials, 2019 - Elsevier
Drug discovery for Parkinson's disease (PD) is challenging. Here we report that gold
nanoclusters (AuNCs) can serve as a novel candidate for the design of anti-PD drugs. With …