New insights into the neurobiology of restless legs syndrome

S Ferré, D García-Borreguero, RP Allen… - The …, 2019 - journals.sagepub.com
Restless legs syndrome (RLS) is a common sensorimotor disorder, whose basic
components include a sensory experience, akathisia, and a sleep-related motor sign …

[HTML][HTML] Pivotal role of adenosine neurotransmission in restless legs syndrome

S Ferré, C Quiroz, X Guitart, W Rea… - Frontiers in …, 2018 - frontiersin.org
The symptomatology of Restless Legs Syndrome (RLS) includes periodic leg movements
during sleep (PLMS), dysesthesias, and hyperarousal. Alterations in the dopaminergic …

The neurophysiology of hyperarousal in restless legs syndrome: Hints for a role of glutamate/GABA

G Lanza, R Ferri - Advances in pharmacology, 2019 - Elsevier
Restless legs syndrome (RLS) is a common sensory-motor circadian disorder, whose basic
components include urge to move the legs, unpleasant sensory experience, and periodic …

Why do restless legs occur at rest?—pathophysiology of neuronal structures in RLS. Neurophysiology of RLS (part 2)

C Trenkwalder, W Paulus - Clinical Neurophysiology, 2004 - Elsevier
Restless legs syndrome (RLS) is a heterogeneous disorder encompassing genetically
caused types with early onset and acquired varieties occurring later in life. Genetic studies in …

Iron, dopamine, genetics, and hormones in the pathophysiology of restless legs syndrome

FH Khan, CD Ahlberg, CA Chow, DR Shah, BB Koo - Journal of neurology, 2017 - Springer
Restless legs syndrome (RLS) is a common, chronic neurologic condition, which causes a
persistent urge to move the legs in the evening that interferes with sleep. Human and animal …

Impairment of sensory-motor integration in patients affected by RLS

V Rizzo, I Arico, G Liotta, L Ricciardi, C Mastroeni… - Journal of …, 2010 - Springer
Much evidence suggests that restless legs syndrome (RLS) is a disorder characterized by
an unsuppressed response to sensory urges due to abnormalities in inhibitory pathways that …

Functional neuroimaging studies in restless legs syndrome

TC Wetter, I Eisensehr, C Trenkwalder - Sleep medicine, 2004 - Elsevier
Functional neuroimaging studies may contribute to elucidate pathophysiological
mechanisms of the restless legs syndrome (RLS) which still remain unclear. Studies in …

The restless legs syndrome

G Barriere, JR Cazalets, B Bioulac, F Tison… - Progress in …, 2005 - Elsevier
The restless legs syndrome (RLS) is one of the commonest neurological sensorimotor
disorders at least in the Western countries and is often associated with periodic limb …

Restless legs syndrome

M Manconi, D Garcia-Borreguero… - Nature reviews Disease …, 2021 - nature.com
Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by an urge
to move that appears during rest or is exacerbated by rest, that occurs in the evening or night …

[HTML][HTML] Restless legs syndrome: known knowns and known unknowns

E Antelmi, L Rocchi, A Latorre, D Belvisi, F Magrinelli… - Brain Sciences, 2022 - mdpi.com
Although restless legs syndrome (RLS) is a common neurological disorder, it remains poorly
understood from both clinical and pathophysiological perspectives. RLS is classified among …