Many inhaled drugs are poorly water soluble, and the dissolution rate is often the rate-
limiting step in the overall absorption process. To improve understanding of pulmonary drug …

The main purpose of this work was to develop an in vitro method for simulating the
dissolution and absorption of inhaled dry powder drugs that also mimics systemic …

The dissolution of inhaled drug particles in the lungs is a challenge to model using
biorelevant methods in terms of (i) collecting a respirable emitted aerosol fraction and …

The unique physiology of the lungs necessitates special considerations for developing a
robust and discriminate dissolution method for orally inhaled drug products (OIDPs). Despite …

Inhalation is the preferred route for the treatment of lung diseases. More recently, also
formulations for systemic treatment have been developed. For efficient development of …

Orally inhaled products (OIPs) are gaining increased attention, as pulmonary delivery is a
preferred route for the treatment of various diseases. Yet, the field of inhalation …

Pulmonary dissolution of poorly soluble drug substances (DSs) may limit the drug
absorption rate and consequently influence clinical performance. Dissolution rate is thus an …

Correlating data from in vitro dissolution testing of inhaled particulate pharmaceuticals or air
pollutants with the dissolution and distribution to the blood circulation of the same aerosols …

In vitro dissolution and permeability testing aid the simulation of the in vivo behavior of
inhalation drug products. Although the regulatory bodies have specific guidelines for the …

Dissolution rate impacts the absorption rate of poorly soluble inhaled drugs. In vitro
dissolution tests that can capture the impact of changes in critical quality attributes of the …