Dysfunctional striatal dopamine signaling in Huntington's disease
ET Koch, LA Raymond - Journal of neuroscience research, 2019 - Wiley Online Library
Dopamine signaling in the striatum is critical for a variety of behaviors including movement,
behavioral flexibility, response to reward and many forms of learning. Alterations to …
behavioral flexibility, response to reward and many forms of learning. Alterations to …
Dopamine and Huntington's disease
LC Schwab, SN Garas, J Drouin-Ouellet… - Expert review of …, 2015 - Taylor & Francis
Huntington's disease (HD) is an incurable, inherited, progressive neurodegenerative
disorder that is defined by a combination of motor, cognitive and psychiatric features. Pre …
disorder that is defined by a combination of motor, cognitive and psychiatric features. Pre …
Dopamine and glutamate in Huntington's disease: a balancing act
VM André, C Cepeda, MS Levine - CNS neuroscience & …, 2010 - Wiley Online Library
Huntington's disease (HD) is caused by a CAG repeat expansion in exon 1 of the HD gene
resulting in a long polyglutamine tract in the N‐terminus of the protein huntingtin. Patients …
resulting in a long polyglutamine tract in the N‐terminus of the protein huntingtin. Patients …
[HTML][HTML] Dysregulation of corticostriatal connectivity in Huntington's disease: a role for dopamine modulation
C Rangel-Barajas, GV Rebec - Journal of Huntington's …, 2016 - content.iospress.com
Aberrant communication between striatum, the main information processing unit of the basal
ganglia, and cerebral cortex plays a critical role in the emergence of Huntington's disease …
ganglia, and cerebral cortex plays a critical role in the emergence of Huntington's disease …
Corticostriatal circuit dysfunction in Huntington's disease: intersection of glutamate, dopamine and calcium
BR Miller, I Bezprozvanny - Future neurology, 2010 - Taylor & Francis
Huntington's disease (HD) is a noncurable and progressive autosomal-dominant
neurodegenerative disorder that results from a polyglutamine expansion in the amino …
neurodegenerative disorder that results from a polyglutamine expansion in the amino …
Dopaminergic signaling and striatal neurodegeneration in Huntington's disease
TS Tang, X Chen, J Liu… - Journal of Neuroscience, 2007 - Soc Neuroscience
Huntington's disease (HD) is a neurodegenerative disorder caused by polyglutamine
(polyQ) expansion in Huntingtin protein (Htt). PolyQ expansion in Httexp causes selective …
(polyQ) expansion in Huntingtin protein (Htt). PolyQ expansion in Httexp causes selective …
[HTML][HTML] Corticostriatal dysfunction in Huntington's disease: the basics
KD Bunner, GV Rebec - Frontiers in human neuroscience, 2016 - frontiersin.org
The main input to the basal ganglia, the corticostriatal pathway, shows some of the earliest
signs of neuropathology in Huntington's disease (HD), an inherited neurodegenerative …
signs of neuropathology in Huntington's disease (HD), an inherited neurodegenerative …
The role of dopamine in Huntington's disease
Alterations in dopamine (DA) neurotransmission in Parkinson's disease are well known and
widely studied. Much less is known about DA changes that accompany and underlie some …
widely studied. Much less is known about DA changes that accompany and underlie some …
[HTML][HTML] Dysregulated neuronal activity patterns implicate corticostriatal circuit dysfunction in multiple rodent models of Huntington's disease
BR Miller, AG Walker, SJ Barton… - Frontiers in systems …, 2011 - frontiersin.org
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that
targets the corticostriatal system and results in progressive deterioration of cognitive …
targets the corticostriatal system and results in progressive deterioration of cognitive …
[HTML][HTML] In vivo Dopamine Efflux is Decreased in Striatum of both Fragment (R6/2) and Full-Length (YAC128) Transgenic Mouse Models of Huntington's Disease
JW Callahan, ED Abercrombie - Frontiers in systems neuroscience, 2011 - frontiersin.org
Huntington's disease (HD) is characterized by numerous alterations within the corticostriatal
circuitry. The striatum is innervated by a dense array of dopaminergic (DA) terminals and …
circuitry. The striatum is innervated by a dense array of dopaminergic (DA) terminals and …
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