Dopamine signaling in the striatum is critical for a variety of behaviors including movement,
behavioral flexibility, response to reward and many forms of learning. Alterations to …

Huntington's disease (HD) is an incurable, inherited, progressive neurodegenerative
disorder that is defined by a combination of motor, cognitive and psychiatric features. Pre …

Huntington's disease (HD) is caused by a CAG repeat expansion in exon 1 of the HD gene
resulting in a long polyglutamine tract in the N‐terminus of the protein huntingtin. Patients …

Aberrant communication between striatum, the main information processing unit of the basal
ganglia, and cerebral cortex plays a critical role in the emergence of Huntington's disease …

Huntington's disease (HD) is a noncurable and progressive autosomal-dominant
neurodegenerative disorder that results from a polyglutamine expansion in the amino …

Huntington's disease (HD) is a neurodegenerative disorder caused by polyglutamine
(polyQ) expansion in Huntingtin protein (Htt). PolyQ expansion in Httexp causes selective …

The main input to the basal ganglia, the corticostriatal pathway, shows some of the earliest
signs of neuropathology in Huntington's disease (HD), an inherited neurodegenerative …

Alterations in dopamine (DA) neurotransmission in Parkinson's disease are well known and
widely studied. Much less is known about DA changes that accompany and underlie some …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that
targets the corticostriatal system and results in progressive deterioration of cognitive …

Huntington's disease (HD) is characterized by numerous alterations within the corticostriatal
circuitry. The striatum is innervated by a dense array of dopaminergic (DA) terminals and …