The surface area of the air/liquid interface in the lungs is substantial, so deposited doses of
aerosol medicines per interface surface area when administered via the inhalation route is …

Purpose The aim of this study was to investigate influencing factors on the dissolution test for
powders for pulmonary delivery with USP apparatus 2 (paddle apparatus). Methods We …

The aim of this research was to investigate a potential standardized test method to
characterize the dissolution properties of formulations intended for pulmonary delivery. A …

Purpose To evaluate different dissolution testing methods and subsequently develop a
simple to perform but reproducible and discriminating dissolution technique for inhalative …

The main purpose of this work was to develop an in vitro method for simulating the
dissolution and absorption of inhaled dry powder drugs that also mimics systemic …

In vitro dissolution testing is routinely used in the development of pharmaceutical products.
Whilst the dissolution testing methods are well established and standardized for oral dosage …

CONCLUSIONS The DissolvIt system successfully differentiated between three compounds
with different physiochemical properties. In this study, differences in the rate of absorption …

Inhalation is the preferred route for the treatment of lung diseases. More recently, also
formulations for systemic treatment have been developed. For efficient development of …

To overcome some of the shortfalls of the types of dissolution testing currently used for
pulmonary products, a new custom-built dissolution apparatus has been developed. For …

Especially for local treatment of lung diseases the respiratory tract is the target for inhalation
medicines. In the future the lungs could also be entrance for inhalation therapies for …