Lineage specification in early development is the basis for the exquisitely precise body plan
of multicellular organisms. It is therefore critical to understand cell fate decisions in early …

In recent years, long noncoding RNAs (lncRNAs) have emerged as an important class of
regulators of gene expression. lncRNAs exhibit several distinctive features that confer …

There is increasing evidence that long noncoding RNAs (lncRNAs) are among the main
regulatory factors of stem cell maintenance and differentiation. They act through various …

LncRNAs have recently emerged as new and fundamental transcriptional and post-
transcriptional regulators acting at multiple levels of gene expression. Indeed, lncRNAs …

Eukaryotic genomes are pervasively transcribed, with tens of thousands of RNAs emanating
from uni-and bi-directional promoters and from active enhancers. In vertebrates, thousands …

Differentiation of specialized cell types from stem and progenitor cells is tightly regulated at
several levels, both during development and during somatic tissue homeostasis. Many long …

A large proportion of the cellular transcriptome of higher vertebrates consists of non-protein
coding transcripts, among them the long noncoding RNAs (lncRNAs). Although lncRNAs are …

Genomes of multicellular organisms are characterized by the pervasive expression of
different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel …

Cellular fate is determined by transcriptional networks and epigenetic states. In addition to
protein factors, noncoding RNAs (ncRNAs), particularly microRNAs and long ncRNAs, are …

Maintenance of the pluripotent state or differentiation of the pluripotent state into any germ
layer depends on the factors that orchestrate expression of thousands of genes through …