Heart failure is the leading cause of death among diabetic people. Cellular and molecular
entities leading to diabetic cardiomyopathy are, however, poorly understood. Coupling of …

Pathological cardiac hypertrophy, the maladaptive remodelling of the myocardium, often
progresses to heart failure. The sodium–proton exchanger (NHE1) and chloride …

Background Diabetes mellitus (DM) has multifactorial detrimental effects on myocardial
tissue. Recently, carbonic anhydrases (CAs) have been shown to play a major role in …

Two AE3 transcripts, full-length (AE3fl) and cardiac (AE3c) are expressed in the heart. AE3
catalyzes electroneutral Cl−/HCO3− exchange across cardiomyocyte sarcolemma. AE …

Key points Carbonic anhydrase enzymes are said to enhance membrane H+ and HCO3−
transport, an idea tested almost exclusively in heterologous cell‐expression systems. In …

Carbonic anhydrase III (CAIII) is abundant in liver, adipocytes, and skeletal muscles, but not
heart. A cytosolic enzyme that catalyzes conversions between CO2 and HCO 3− in the …

Diabetic heart dysfunctions during cardiac surgeries have revealed several clinical
problems associated with ion imbalance. However, the mechanism of ion imbalance …

Na+/HCO3− cotransporter (NBC) e1 catalyze the electrogenic movement of 1 Na+: 2 HCO3−
into cardiomyocytes cytosol. NBC proteins associate with carbonic anhydrases (CA), CAII …

Hypertrophic cardiomyocyte growth contributes substantially to the progression of heart
failure. Activation of the plasma membrane Na+–H+ exchanger (NHE1) and Cl−–HCO3 …

Background Carbonic anhydrase enzymes (CA) catalyze the reversible hydration of carbon
dioxide to bicarbonate in mammalian cells. Trans-membrane transport of CA-produced …