Abstract The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine
fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …

Endocrine fibroblast growth factors (FGFs) have been recognized as hormones that regulate
a variety of metabolic processes. FGF19 is secreted from intestine upon feeding and acts on …

Background: Membrane αKlotho (hereinafter called Klotho) is highly expressed in the kidney
and functions as a coreceptor of FGF receptors (FGFRs) to activate specific fibroblast growth …

Endocrine fibroblast growth factors (FGFs) control a variety of physiological processes
including suppression of bile acid synthesis in hepatocytes, promotion of lipolysis in …

FGF19 subfamily proteins (FGF19, FGF21, and FGF23) are unique members of fibroblast
growth factors (FGFs) that regulate energy, bile acid, glucose, lipid, phosphate, and vitamin …

The klotho gene (KL) was identified first as a putative aging-suppressor gene that extended
life span when overexpressed and accelerated aging-like phenotypes when disrupted in …

Through alternative splicing, Klotho protein exists both as a secreted and a membrane form
whose extracellular domain could be shed from the cell surface by secretases and released …

FGF23 is a bone-derived hormone that acts primarily on the kidney to induce phosphaturia
and suppress synthesis of 1, 25-dihydroxyvitamin D 3. The unique feature of FGF23 is that it …

The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-
suppressor gene, which extends lifespan when overexpressed and accelerates the …

The klotho gene encodes a single-pass transmembrane protein that forms a complex with
multiple fibroblast growth factor (FGF) receptors and functions as an obligatory co-receptor …