Serum concentrations of oocyte-secreted factors BMP15 and GDF9 during IVF and in women with reproductive pathologies

AH Riepsamen, K Chan, S Lien, P Sweeten… - …, 2019 - academic.oup.com
Oocyte-secreted factors bone morphogenetic protein 15 (BMP15) and growth differentiation
factor 9 (GDF9) are critical for folliculogenesis and fertility. This study developed ELISAs for …

Serum GDF9 and BMP15 as potential markers of ovarian function in women with and without polycystic ovary syndrome

AH Riepsamen, MW Donoghoe, IR Indran… - Clinical …, 2023 - Wiley Online Library
Objective Growth differentiation factor‐9 (GDF9) and bone morphogenetic protein‐15
(BMP15) are critical paracrine regulators of female fertility and are predominantly expressed …

[HTML][HTML] Exploratory analysis of serum concentrations of oocyte biomarkers growth differentiation factor 9 and bone morphogenetic protein 15 in ovulatory women …

AH Riepsamen, MW Donoghoe, A Baerwald… - Fertility and …, 2021 - Elsevier
Objective To characterize and evaluate the variation in serum concentrations of oocyte-
secreted growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) …

Intrafollicular concentrations of the oocyte-secreted factors GDF9 and BMP15 vary inversely in polycystic ovaries

SG Kristensen, A Kumar, LS Mamsen… - The Journal of …, 2022 - academic.oup.com
Context The oocyte-secreted factors growth differentiation factor 9 (GDF9) and bone
morphogenetic protein 15 (BMP15) play essential roles in follicle development and oocyte …

[HTML][HTML] Influence of follicular fluid GDF9 and BMP15 on embryo quality

F Gode, B Gulekli, E Dogan, P Korhan, S Dogan… - Fertility and sterility, 2011 - Elsevier
Objective To evaluate the association between follicular fluid levels of propeptide and
mature forms of growth differentiation factor (GDF) 9 and bone morphogenetic protein (BMP) …

Reduced and delayed expression of GDF9 and BMP15 in ovarian tissues from women with polycystic ovary syndrome

LN Wei, R Huang, LL Li, C Fang, Y Li… - Journal of assisted …, 2014 - Springer
Purpose Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15)
play crucial roles in follicular development and oocyte maturation. This study aimed to …

[HTML][HTML] Increased GDF9 and BMP15 mRNA levels in cumulus granulosa cells correlate with oocyte maturation, fertilization, and embryo quality in humans

Y Li, RQ Li, SB Ou, NF Zhang, L Ren, LN Wei… - Reproductive biology …, 2014 - Springer
Abstract Background Oocyte secreted factors (OSFs), including growth differentiation factor 9
(GDF9) and bone morphogenetic protein 15 (BMP15), play an important role in the process …

[HTML][HTML] Abnormal expression of growth differentiation factor 9 and bone morphogenetic protein 15 in stimulated oocytes during maturation from women with polycystic …

LN Wei, XY Liang, C Fang, MF Zhang - Fertility and sterility, 2011 - Elsevier
OBJECTIVE: To investigate the expression pattern of two oocyte-secreted factors—growth
differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BM15)—during oocyte …

High bone morphogenetic protein-15 level in follicular fluid is associated with high quality oocyte and subsequent embryonic development

YT Wu, L Tang, J Cai, XE Lu, J Xu, XM Zhu… - Human …, 2007 - academic.oup.com
BACKGROUND Bone morphogenetic protein-15 (BMP-15) has been shown to influence
oocyte maturation and quality. However, no relationship has been established between …

GDF-9 and BMP-15 direct the follicle symphony

A Sanfins, P Rodrigues, DF Albertini - Journal of assisted reproduction and …, 2018 - Springer
Understanding the physiology underlying the complex dialog between the oocyte and its
surrounding somatic cells within the ovarian follicle has been crucial in defining optimal …