Insulin is a peptide hormone produced by the pancreas to regulate the cells intake of
glucose in the blood. Type 1 diabetes compromises this particular capacity of the pancreas …

The glycemia regulation is a significant challenge in the Artificial Pancreas (AP) scenario.
Several control systems have been developed in the last years, many of them requiring meal …

Patients with type 1 diabetes mellitus (T1DM) need to supply their body with insulin from
external sources in order to manage their blood glucose (BG) concentration and mitigate the …

The achievement of closed-loop glycemic control, and hence the automation of insulin
administration, is highly required in the implementation of an Artificial Pancreas system …

Closed-loop glycemic control algorithms have demonstrated the ability to improve glucose
regulation in patients with type 1 diabetes mellitus (T1D), both in silico and clinical trials …

We study predictive control for blood glucose regulation in patients with type 1 diabetes
mellitus. We determine optimal control actions for insulin and glucagon infusion via linear …

In this work a continuous-time MPC scheme is presented for linear systems under Signal
Temporal Logic (STL) specifications and input constraints. The satisfaction of the STL …

This paper presents a methodology to tune an artificial pancreas controller by minimizing the
time spent in endangering glycaemic ranges (hypo-and hyperglycaemia). The risk …

The human insulin-glucose metabolism is a time-varying process, which is partly caused by
the changing insulin sensitivity of the body. This insulin sensitivity follows a circadian rhythm …

The control design of an artificial pancreas, a hot research topic in diabetology, is tackled via
the newly introduced model-free control and its corresponding “intelligent” proportional …