Background: Psoriasis is a chronic, life-long inflammatory disorder that primarily affects the
skin. The etiopathogenesis of psoriasis remains elusive. The activation of the NF-ҡB/Rel …

CD137, a member of the tumor necrosis factor receptor superfamily of cell surface proteins,
acts as a costimulatory receptor on T cells, natural killer cells, B cell subsets, and some …

Colorectal cancer (CRC) is the fourth most common cancer in the UK and despite earlier
detection and improved treatments, it remains the second most common cause of cancer …

Die NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells)-Untereinheit RelB
ist für seine duale Funktion als Aktivator und Repressor der NF-κB-abhängigen …

Two key events are associated with IKK activation through the canonical NF-kB pathway.
Phosphorylation of two serine residues within the activation loop (AL) of IKK2/β has long be …

One of the characteristic traits of RA is the expansion of a thin synovial membrane into a
grossly enlarged invasive structure named the pannus. FLS are a key cellular constituent of …

Regulatory B cells (Bregs) play a critical role in the control of autoimmunity and
inflammation. IL-10 production is the hallmark for the identification of Bregs. However, the …

Allergic diseases are the most frequent chronic diseases in childhood [1] and one important
manifestation is asthma. This pulmonary disease presents with airway hyperresponsiveness …

Ve výzkumu onemocnění centrální nervové soustavy stále více vyvstává význam TLR
dependentní signalizace v mikrogliích. Jak MyD88 závislá, tak TRIF závislá dráha, které …

Allergic diseases are the most frequent chronic diseases in childhood [1] and one important
manifestation is asthma. This pulmonary disease presents with airway hyperresponsiveness …