Tyrosine kinase receptors (TKR) comprise more than 60 molecules that play an essential
role in the molecular pathways, leading to cell survival and differentiation. Consequently …

Introduction Frequently, patients with locally advanced or metastatic NSCLC are screened
for mutations and fusions. In most laboratories, molecular workup includes a multitude of …

Tumor-derived exosomes (TEXs) contain enriched miRNAs that act as novel non-invasive
biomarkers for cancer diagnosis and play a role in cancer progression. We investigated the …

PURPOSE To evaluate the efficacy of pemetrexed plus cisplatin versus vinorelbine plus
cisplatin as postoperative adjuvant chemotherapy in patients with pathologic stage II-IIIA …

Before the introduction of tyrosine kinase inhibitors (TKIs) for a particular subgroup of
patients, despite platinum-based combination chemotherapy, the majority of patients …

Background We sought to assess the relative effects of individual anaplastic lymphoma
kinase (ALK) inhibitors for the treatment of non-small cell lung cancer (NSCLC). Methods We …

Genomic testing enables clinical management to be tailored to individual cancer patients
based on the molecular alterations present within cancer cells. Genomic sequencing results …

Lung cancer is a major global health problem. Several strategies are required to conquer
this cancer. Stricter implementations of tobacco control measures are necessary. Early …

Introduction Next-generation sequencing (NGS) based on genomic DNA has been widely
applied for gene rearrangement detection in patients with NSCLC. However, intergenic …

Numerous protein kinases encoded in the genome have become attractive targets for the
treatment of different types of cancer. As of January 2020, a total of 52 small-molecule …