This study reports the synthesis of a series of 2-aroylisoindoline hydroxamic acids
employing N-benzyl, long alkyl chain and acrylamide units as diverse linkers. In-vitro studies …

Lung-cancer is the foremost cause of cancer in humans worldwide, of which 80–85% cases
are composed of non-small cell lung carcinoma. All treatment decisions depend on the …

Lung cancer incidence has increased worldwide over the past decades, with non‐small cell
lung cancer (NSCLC) accounting for the vast majority (85%) of lung cancer specimens. It is …

Introduction: Survival of ALK-rearranged NSCLC patients has dramatically improved by the
use of multiple ALK-tyrosine kinase inhibitors (ALK-TKI). However, still little is known about …

Background Glioblastoma is an uncommon but highly aggressive type of brain tumour.
Significant gains have been achieved in the molecular understanding and the pathogenesis …

Lung adenocarcinoma is the most frequently diagnosed subtype of nonsmall cell lung
cancer. The molecular mechanisms of the initiation and progression of lung …

Background The treatment of choice for advanced non–small cell lung cancer is selected
according to the presence of specific alterations. Patients should undergo molecular testing …

Background Canada has an established publicly funded health care system with a complex
drug approval and funding process. After proof of efficacy (POE; key publication/presentation …

Precision medicine is a promising strategy for cancer treatment. In this study, we developed
an in‐house clinical sequencing system to perform a comprehensive cancer genomic …

Non–small cell lung cancer (NSCLC) is a heterogeneous disease, commonly defined by
genetic alterations in oncogenic drivers. Targeted therapies have transformed the …