[HTML][HTML] Anaplastic lymphoma kinase rearrangement may increase the incidence of venous thromboembolism by increasing tissue factor expression in advanced lung …

S Yang, L Yang, Y Wu, C Zhang, S Wang… - Annals of …, 2020 - ncbi.nlm.nih.gov
Background Patients with lung cancer are at an increased risk for venous thromboembolism
(VTE). Approximately 8–15% of patients with advanced non-small-cell lung cancer (NSCLC) …

Therapeutic landscape of metastatic non-small-cell lung cancer in Canada in 2020

A Elkrief, P Joubert, M Florescu, M Tehfe, N Blais… - Current …, 2020 - mdpi.com
Lung cancer is the most commonly diagnosed cancer in Canada and remains associated
with high mortality. Nevertheless, recent advances in the fields of immuno-oncology and …

[HTML][HTML] Non-small cell lung cancer from genomics to therapeutics: A framework for community practice integration to arrive at personalized therapy strategies

S Rajurkar, I Mambetsariev, R Pharaon… - Journal of Clinical …, 2020 - mdpi.com
Non-small cell lung cancer (NSCLC) is a heterogeneous disease, and therapeutic
management has advanced with the identification of various key oncogenic mutations that …

[HTML][HTML] Does pemetrexed work in targetable, nonsquamous non-small-cell lung cancer? A narrative review

JY Shih, A Inoue, R Cheng, R Varea, SW Kim - Cancers, 2020 - mdpi.com
Simple Summary The chemotherapy agent pemetrexed is currently considered in
combination with other therapies for the treatment of advanced nonsquamous non-small-cell …

Efficacy and safety of ALK inhibitors in ALK-rearranged non-small cell lung cancer: a systematic review and meta-analysis

D Breadner, P Blanchette, S Shanmuganathan… - Lung Cancer, 2020 - Elsevier
Objectives No overall survival (OS) benefit has been reported from a mature randomized
trial with the use of ALK inhibitors. We conducted a systematic review and meta-analysis to …

[HTML][HTML] Coexistence of a novel CCNY-ALK and ATIC-ALK double-fusion in one patient with ALK-positive NSCLC and response to crizotinib: a case report

X Wu, H Zhou, Z He, Z Zhang, W Feng… - Translational Lung …, 2020 - ncbi.nlm.nih.gov
Anaplastic lymphoma kinase (ALK) rearrangement, one of the common oncogene
rearrangements in the mutational history of lung adenocarcinoma, occurs in approximately …

[HTML][HTML] Prevalence and clinical impact of concomitant mutations in anaplastic lymphoma kinase rearrangement advanced non-small-cell lung cancer (Guangdong …

M Li, X Hou, C Zhou, W Feng, G Jiang, H Long… - Frontiers in …, 2020 - frontiersin.org
Background: In patients with anaplastic lymphoma kinase (ALK) rearrangement-positive
advanced non–small-cell lung cancer (NSCLC), ALK inhibitors are now the standard …

Paired genetic analysis by next‐generation sequencing of lung cancer and associated idiopathic pulmonary fibrosis

K Otsubo, E Iwama, K Ijichi, N Kubo… - Cancer …, 2020 - Wiley Online Library
The pathogenesis of lung cancer associated with idiopathic pulmonary fibrosis (IPF) has
remained largely uncharacterized. To provide insight into this condition, we undertook …

[HTML][HTML] Molecular profiling of non-small cell lung cancer

ML Forsythe, A Alwithenani, D Bethune… - PLoS …, 2020 - journals.plos.org
Lung cancer is generally treated with conventional therapies, including chemotherapy and
radiation. These methods, however, are not specific to cancer cells and instead attack every …

A trial of the safety and efficacy of chemotherapy plus anlotinib vs chemotherapy alone as second-or third-line salvage treatment for advanced non-small cell lung …

H Wang, J Chu, Y Zhao, H Tang, L Wang… - Cancer Management …, 2020 - Taylor & Francis
Purpose Anlotinib is a newly developed oral multitarget tyrosine kinase inhibitor. We
retrospectively evaluated the toxicity and clinical efficacy of chemotherapy combined with …