[HTML][HTML] Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis
Physical activity has been associated with lower risks of breast and colorectal cancer in
epidemiological studies; however, it is unknown if these associations are causal or …
epidemiological studies; however, it is unknown if these associations are causal or …
The genetics of human ageing
The past two centuries have witnessed an unprecedented rise in human life expectancy.
Sustaining longer lives with reduced periods of disability will require an understanding of the …
Sustaining longer lives with reduced periods of disability will require an understanding of the …
Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study
Objective To evaluate whether body size in early life has an independent effect on risk of
disease in later life or whether its influence is mediated by body size in adulthood. Design …
disease in later life or whether its influence is mediated by body size in adulthood. Design …
[HTML][HTML] Smoking, alcohol consumption, and cancer: A mendelian randomisation study in UK Biobank and international genetic consortia participants
SC Larsson, P Carter, S Kar, M Vithayathil… - PLoS …, 2020 - journals.plos.org
Background Smoking is a well-established cause of lung cancer and there is strong
evidence that smoking also increases the risk of several other cancers. Alcohol consumption …
evidence that smoking also increases the risk of several other cancers. Alcohol consumption …
[HTML][HTML] The role of polygenic risk and susceptibility genes in breast cancer over the course of life
N Mars, E Widén, S Kerminen, T Meretoja… - Nature …, 2020 - nature.com
Polygenic risk scores (PRS) for breast cancer have potential to improve risk prediction, but
there is limited information on their utility in various clinical situations. Here we show that …
there is limited information on their utility in various clinical situations. Here we show that …
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells
Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the
excessive production of mature myeloid cells and arise from the acquisition of somatic driver …
excessive production of mature myeloid cells and arise from the acquisition of somatic driver …
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes
Genome-wide association studies have identified breast cancer risk variants in over 150
genomic regions, but the mechanisms underlying risk remain largely unknown. These …
genomic regions, but the mechanisms underlying risk remain largely unknown. These …
[HTML][HTML] European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European
women, but their utility in Asian women is unclear. Here we evaluate the best performing …
women, but their utility in Asian women is unclear. Here we evaluate the best performing …
[HTML][HTML] Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction
L Kachuri, RE Graff, K Smith-Byrne, TJ Meyers… - Nature …, 2020 - nature.com
Cancer risk is determined by a complex interplay of environmental and heritable factors.
Polygenic risk scores (PRS) provide a personalized genetic susceptibility profile that may be …
Polygenic risk scores (PRS) provide a personalized genetic susceptibility profile that may be …
Trends of female and male breast cancer incidence at the global, regional, and national levels, 1990–2017
Purpose Breast cancer is a major public health concern worldwide and shows significant
heterogeneity between male and female. Knowing the global incidence landscape in both …
heterogeneity between male and female. Knowing the global incidence landscape in both …