Aortic valve calcification leads to the deposition of calcium phosphate minerals in the
extracellular matrix of the aortic valve leaflets. The mineral deposits can severely narrow the …

Background MAVD, defined as severe aortic stenosis with moderate or severe aortic
regurgitation, is frequently encountered in clinical practice. However, the data regarding …

Objectives To evaluate risk factors for prevalence and progression of aortic valve
calcification (AVC) in lung cancer screening participants and also to assess the sensitivity …

Background Compared to high gradient aortic stenosis (AS), patients with low-flow, low-
gradient AS have higher mortality after transcatheter aortic valve replacement (TAVR), but …

Normal-flow low-gradient severe aortic stenosis (NF-LG-SAS), defined by an aortic valve
area (AVA)< 1 cm², mean pressure gradient (MPG)< 40 mm Hg and indexed stroke …

Background Aortic valve calcification severity has been associated with higher rates of aortic
regurgitation (AR) following TAVR, but scarce data exist on its impact with the use of newer …

Abstract Background LDLr−/−/ApoB 100/100/IGF-II+/− mice are used as a calcific aortic
valve disease (CAVD) model. However, normal aortic valve hemodynamics ie remotely from …

Aortic stenosis (AS) is a disease of the valve and the myocardium. A correct assessment of
the valve disease severity is key to define the need for aortic valve replacement (AVR), but a …

Objective Circulating biomarkers are useful in detection and monitoring of cardiovascular
diseases. However, their role in aortic valve disease is unclear. Mechanisms are rapidly …

Background: The 2017 European Society of Cardiology guidelines for valvular heart disease
included changes in the definition of severe aortic stenosis (AS). We wanted to evaluate its …