Cocaine-induced ischemia in prefrontal cortex is associated with escalation of cocaine intake in rodents
Cocaine-induced vasoconstriction reduces blood flow, which can jeopardize neuronal
function and in the prefrontal cortex (PFC) it may contribute to compulsive cocaine intake …
function and in the prefrontal cortex (PFC) it may contribute to compulsive cocaine intake …
[HTML][HTML] Ca2+ channel blockade reduces cocaine's vasoconstriction and neurotoxicity in the prefrontal cortex
Cocaine profoundly affects both cerebral blood vessels and neuronal activity in the brain.
The vasoconstrictive effects of cocaine, concurrently with its effects on neuronal [Ca2+] i …
The vasoconstrictive effects of cocaine, concurrently with its effects on neuronal [Ca2+] i …
Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: optical imaging study in anesthetized …
Cocaine addiction is associated with dysfunction of the prefrontal cortex (PFC), which
facilitates relapse and compulsive drug taking. To assess if cocaine's effects on both …
facilitates relapse and compulsive drug taking. To assess if cocaine's effects on both …
Cocaine attenuates blood flow but not neuronal responses to stimulation while preserving neurovascular coupling for resting brain activity
Cocaine affects neuronal activity and constricts cerebral blood vessels, making it difficult to
determine whether cocaine-induced changes in cerebral blood flow (CBF) reflect neuronal …
determine whether cocaine-induced changes in cerebral blood flow (CBF) reflect neuronal …
[HTML][HTML] Neurovascular effects of cocaine: relevance to addiction
Cocaine is a highly addictive drug, and its use is associated with adverse medical
consequences such as cerebrovascular accidents that result in debilitating neurological …
consequences such as cerebrovascular accidents that result in debilitating neurological …
Cocaine-induced cortical microischemia in the rodent brain: clinical implications
Cocaine-induced stroke is among the most serious medical complications associated with
its abuse. However, the extent to which acute cocaine may induce silent microischemia …
its abuse. However, the extent to which acute cocaine may induce silent microischemia …
Abnormal brain activation to visual stimulation in cocaine abusers
JH Lee, FW Telang, CS Springer Jr, ND Volkow - Life sciences, 2003 - Elsevier
Chronic cocaine abuse has been associated with cerebrovascular pathology. This is likely to
reflect its vasoactive effects; cocaine produces vasoconstriction and reduces cerebral blood …
reflect its vasoactive effects; cocaine produces vasoconstriction and reduces cerebral blood …
[HTML][HTML] Cocaine's cerebrovascular vasoconstriction is associated with astrocytic Ca2+ increase in mice
Human and animal studies have reported widespread reductions in cerebral blood flow
associated with chronic cocaine exposures. However, the molecular and cellular …
associated with chronic cocaine exposures. However, the molecular and cellular …
Astrocytes modulate cerebral blood flow and neuronal response to cocaine in prefrontal cortex
C Du, K Park, Y Hua, Y Liu, ND Volkow, Y Pan - Molecular Psychiatry, 2024 - nature.com
Cocaine affects both cerebral blood vessels and neuronal activity in brain. Cocaine can also
disrupt astrocytes, which modulate neurovascular coupling—a process that regulates …
disrupt astrocytes, which modulate neurovascular coupling—a process that regulates …
[HTML][HTML] Chronic cocaine induces HIF-VEGF pathway activation along with angiogenesis in the brain
W Yin, K Clare, Q Zhang, ND Volkow, C Du - PLoS One, 2017 - journals.plos.org
Cocaine induces vasoconstriction in cerebral vessels, which with repeated use can result in
transient ischemic attacks and cerebral strokes. However, the neuroadaptations that follow …
transient ischemic attacks and cerebral strokes. However, the neuroadaptations that follow …