Cocaine-induced structural and functional impairments of the glymphatic pathway in mice

W Chen, P Huang, H Zeng, J Lin, Z Shi… - Brain, Behavior, and …, 2020 - Elsevier
The glymphatic system plays a central role in the clearance of extracellular wastes from the
brain. Cocaine exposure can lead to pathologies that affect the entire brain, resulting in …

Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: optical imaging study in anesthetized …

CP Allen, K Park, A Li, ND Volkow, GF Koob… - Addiction …, 2019 - Wiley Online Library
Cocaine addiction is associated with dysfunction of the prefrontal cortex (PFC), which
facilitates relapse and compulsive drug taking. To assess if cocaine's effects on both …

A novel conceptual framework for the functionality of the glymphatic system

K Astara, C Pournara, ER de Natale… - Journal of …, 2023 - journals.physiology.org
The glymphatic system is responsible for the clearance of the potentially harmful metabolic
waste of the central nervous system. The prevalent theory is that the cerebrospinal fluid …

Chronic stress impairs the aquaporin-4-mediated glymphatic transport through glucocorticoid signaling

F Wei, J Song, C Zhang, J Lin, R Xue, LD Shan… - …, 2019 - Springer
Background The glymphatic system has recently been proposed to function as a brain-wide
macroscopic system for the clearance of potentially harmful molecules, such as amyloid beta …

Glymphatic system: an emerging therapeutic approach for neurological disorders

Y Gao, K Liu, J Zhu - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
The functions of the glymphatic system include clearance of the metabolic waste and
modulation of the water transport in the brain, and it forms a brain-wide fluid network along …

The glymphatic system: implications for drugs for central nervous system diseases

TJ Lohela, TO Lilius, M Nedergaard - Nature Reviews Drug Discovery, 2022 - nature.com
In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …

Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia

LM Hablitz, HS Vinitsky, Q Sun, FF Stæger… - Science …, 2019 - science.org
The glymphatic system is responsible for brain-wide delivery of nutrients and clearance of
waste via influx of cerebrospinal fluid (CSF) alongside perivascular spaces and through the …

Repetitive mild traumatic brain injury alters glymphatic clearance rates in limbic structures of adolescent female rats

J Christensen, DK Wright, GR Yamakawa, SR Shultz… - Scientific reports, 2020 - nature.com
The glymphatic system is the macroscopic waste clearance system for the central nervous
system. Glymphatic dysfunction has been linked to several neurological conditions …

Chronic cocaine administration causes extensive white matter damage in brain: diffusion tensor imaging and immunohistochemistry studies

PA Narayana, JJ Herrera, KH Bockhorst… - Psychiatry Research …, 2014 - Elsevier
The effect of chronic cocaine exposure on multiple white matter structures in rodent brain
was examined using diffusion tensor imaging (DTI), locomotor behavior, and end point …

The brain's glymphatic system: drawing new perspectives in neuroscience

AV Ciurea, AG Mohan, RA Covache-Busuioc… - Brain Sciences, 2023 - mdpi.com
This paper delves into the intricate structure and functionality of the brain's glymphatic
system, bringing forth new dimensions in its neuroscientific understanding. This paper …