TMEM119 as a specific marker of microglia reaction in traumatic brain injury in postmortem examination

S Bohnert, A Seiffert, S Trella, M Bohnert… - International Journal of …, 2020 - Springer
The aim of the present study was a refined analysis of neuroinflammation including
TMEM119 as a useful microglia-specific marker in forensic assessments of traumatic causes …

Fast microglial activation after severe traumatic brain injuries

J Lier, B Ondruschka, I Bechmann, J Dreßler - International journal of legal …, 2020 - Springer
Traumatic brain injury is among the leading causes of death in individuals under 45 years of
age. However, since trauma mechanisms and survival times differ enormously, the exact …

Protein expression of the microglial marker Tmem119 decreases in association with morphological changes and location in a mouse model of traumatic brain injury

D Mercurio, S Fumagalli, MKH Schafer… - Frontiers in Cellular …, 2022 - frontiersin.org
The activation of microglia and the infiltration of macrophages are hallmarks of
neuroinflammation after acute brain injuries, including traumatic brain injury (TBI). The two …

Macrophage subsets in mechanical brain injury (MBI)–a contribution to timing of MBI based on immunohistochemical methods: a pilot study

M Oehmichen, S Jakob, S Mann, KS Saternus, I Pedal… - Legal Medicine, 2009 - Elsevier
Cortical hemorrhages as a consequence of closed mechanical brain injury (MBI) trigger an
inflammatory response including a distinct increase of macrophages. According to published …

Can quantifying morphology and TMEM119 expression distinguish between microglia and infiltrating macrophages after ischemic stroke and reperfusion in male and …

KF Young, R Gardner, V Sariana, SA Whitman… - Journal of …, 2021 - Springer
Background Ischemic stroke is an acquired brain injury with gender-dependent outcomes. A
persistent obstacle in understanding the sex-specific neuroinflammatory contributions to …

Quantitative immunohistochemical analysis of myeloid cell marker expression in human cortex captures microglia heterogeneity with anatomical context

MEV Swanson, HC Murray, B Ryan, RLM Faull… - Scientific reports, 2020 - nature.com
Current immunohistochemical methods of studying microglia in the post-mortem human
brain do not capture the heterogeneity of microglial function in response to damage and …

Microglia activation as a biomarker for traumatic brain injury

DG Hernandez-Ontiveros, N Tajiri, S Acosta… - Frontiers in …, 2013 - frontiersin.org
Traumatic brain injury (TBI) has become the signature wound of wars in Afghanistan and
Iraq. Injury may result from a mechanical force, a rapid acceleration-deceleration movement …

A new understanding of TMEM119 as a marker of microglia

C Ruan, W Elyaman - Frontiers in cellular neuroscience, 2022 - frontiersin.org
Neuroinflammation is a hallmark of many neurological diseases, including traumatic brain
injury (TBI), which is usually characterized by two pathological hallmarks: activation of …

Widespread microglial activation in patients deceased from traumatic brain injury

A Velázquez, M Ortega, S Rojas, FJ González-Oliván… - Brain injury, 2015 - Taylor & Francis
Primary objective: The role of microglial activation in traumatic brain injury (TBI) has been
extensively described in established animal models. In contrast, very few studies have …

High-resolution and differential analysis of rat microglial markers in traumatic brain injury: conventional flow cytometric and bioinformatics analysis

N Toledano Furman, A Gottlieb, KS Prabhakara… - Scientific Reports, 2020 - nature.com
Traumatic brain injury (TBI) results in a cascade of cellular responses, which produce
neuroinflammation, partly due to microglial activation. Transforming from surveying to …