Hypercoagulability can occur after severe tissue injury, that is likely related to tissue factor
exposure and impaired endothelial release of tissue plasminogen activator (tPA). In contrast …

There is no standard definition for trauma-induced coagulopathy (TIC). However, it could be
defined as an abnormal hemostatic response secondary to trauma. The terms “early TIC” …

Trauma-induced coagulopathy (TIC) is a heterogeneous entity that contributes to a
significant morbidity and mortality following trauma. The activated protein C system …

Abnormal coagulation parameters can be found in 25% of trauma patients with major
injuries. Furthermore, trauma patients presenting with coagulopathy on admission have …

The identification and management of coagulopathy is a critical component of caring for the
severely injured patient. Notions of the mechanisms of coagulopathy in trauma patients have …

Background Major trauma is a leading cause of morbidity and mortality worldwide with
hemorrhage accounting for 40% of deaths. Acute traumatic coagulopathy exacerbates …

Trauma-induced coagulopathy (TIC) is a clinical scenario spanning the spectrum of
hypocoagulability to hypercoagulability causing a wide range of complications including …

Trauma remains a leading cause of death worldwide, and most early preventable deaths in
both the civilian and military settings are due to uncontrolled hemorrhage, despite paradigm …

Background: Bleeding is the most frequent cause of preventable death after severe injury.
Coagulopathy associated with severe injury complicates the control of bleeding and is …

The concept of impaired coagulation following injury has been the subject of scientific
investigation for a century, 1 but defining the responsible mechanisms to guide …