Transcriptional memory allows certain genes to respond to previously experienced signals
more robustly. However, whether and how the key proinflammatory cytokine TNF-α mediates …

Fibroblast-like synoviocytes (FLS) play a critical role in the pathogenesis of rheumatoid
arthritis (RA). Chronic inflammation induces transcriptomic and epigenetic modifications that …

Memory T cells play an essential role in protecting against infectious diseases and cancer
and contribute to autoimmunity and transplant rejection. Understanding how they are …

Background Immunological memory is the ability of the immune system to respond more
rapidly and effectively to previously encountered pathogens, a key feature of adaptive …

TNFα gene expression is silenced in the endotoxin tolerant phenotype that develops in
blood leukocytes after the initial activation phase of severe systemic inflammation or sepsis …

Many scenarios in cellular communication require cells to interpret multiple dynamic signals.
It is unclear how exposure to inflammatory stimuli alters transcriptional responses to …

Pathogen-derived lipopolysaccharide (LPS) and cytokine tumor necrosis factor (TNF)
activate NFκB with distinct duration dynamics, but how immune response genes decode …

The relationship between TNF and immune pathology forced an intense research into the
regulation of its biosynthesis that extends to multiple mechanisms controlling the utilization …

Long-term memory formation requires selective changes in gene expression. Here, we
determined the contribution of chromatin remodeling to learning-induced changes in brain …

Memory T cells are distinguished from naive T cells by their rapid production of effector
cytokines, although mechanisms for this recall response remain undefined. In this study, we …