[PDF][PDF] Excessive folic acid supplementation in pregnant mice impairs insulin secretion and induces the expression of genes associated with fatty liver in their offspring

Y Kintaka, N Wada, S Shioda, S Nakamura… - Heliyon, 2020 - cell.com
Objective Previous human and animal studies have shown that excessive maternal intake of
folic acid (FA) predisposes to impaired glucose tolerance in the offspring. However, the …

[HTML][HTML] Maternal high folic acid supplement promotes glucose intolerance and insulin resistance in male mouse offspring fed a high-fat diet

Y Huang, Y He, X Sun, Y He, Y Li, C Sun - International journal of …, 2014 - mdpi.com
Maternal nutrition may influence metabolic profiles in offspring. We aimed to investigate the
effect of maternal folic acid supplement on glucose metabolism in mouse offspring fed a high …

Maternal and postweaning folic acid supplementation interact to influence body weight, insulin resistance, and food intake regulatory gene expression in rat offspring …

PSP Huot, A Ly, IMY Szeto… - Applied Physiology …, 2016 - cdnsciencepub.com
Maternal intake of multivitamins or folic acid above the basal dietary requirement alters the
growth and metabolic trajectory of rat offspring. We hypothesized that a modest increase in …

High-dose perinatal folic-acid supplementation alters insulin sensitivity in Sprague-Dawley rats and diminishes the expression of adiponectin

AO Morakinyo, TA Samuel, FO Awobajo… - Journal of Dietary …, 2019 - Taylor & Francis
The possible intake of folate in excess of the recommended upper levels is a matter of
critical importance. This study was conducted to investigate the effects of prenatal and …

Metabolic effects of a high‐fat diet post‐weaning after low maternal dietary folate during pregnancy and lactation

JA McKay, L Xie, C Manus, SAS Langie… - Molecular nutrition & …, 2014 - Wiley Online Library
Scope Investigate the influence of low‐folate supply during pregnancy and lactation on
obesity and markers of the metabolic syndrome in offspring, and how provision of a high‐fat …

[HTML][HTML] Maternal Prenatal Folic Acid Supplementation Programs Offspring Lipid Metabolism by Aberrant DNA Methylation in Hepatic ATGL and Adipose LPL in Rats

X Yang, Y Huang, C Sun, J Li - Nutrients, 2017 - mdpi.com
The effects of maternal prenatal folic acid supplementation (FAS) on offspring lipid
metabolism in adulthood remains unclear, although prenatal FAS is compulsively suggested …

[HTML][HTML] Effects of folic acid supplementation in pregnant mice on glucose metabolism disorders in male offspring induced by lipopolysaccharide exposure during …

WX Sun, YP Shu, XY Yang, W Huang, J Chen… - Scientific Reports, 2023 - nature.com
The DOHaD theory suggests that adverse environmental factors in early life may lead to the
development of metabolic diseases including diabetes and hypertension in adult offspring …

Maternal folate status and obesity/insulin resistance in the offspring: a systematic review

RH Xie, YJ Liu, R Retnakaran, AJ MacFarlane… - International Journal of …, 2016 - nature.com
OBJECTIVE: Prenatal folic acid supplementation or maternal folate sufficiency may protect
the offspring from obesity and insulin resistance. This study aims to summarize the findings …

[HTML][HTML] Protein and folic acid content in the maternal diet determine lipid metabolism and response to high-fat feeding in rat progeny in an age-dependent manner

A Chmurzynska, M Stachowiak, J Gawecki… - Genes & nutrition, 2012 - Springer
Maternal diet during gestation can exert a long-term effect on the progeny's health by
programming their developmental scheme and metabolism. The aim of this study is to …

[HTML][HTML] Folate treatment of pregnant rat dams abolishes metabolic effects in female offspring induced by a paternal pre-conception unhealthy diet

J Li, YP Lu, O Tsuprykov, AA Hasan, C Reichetzeder… - Diabetologia, 2018 - Springer
Aims/hypothesis Paternal high-fat diet prior to mating programmes impaired glucose
tolerance in female offspring. We examined whether the metabolic consequences in …