DNA-based microarray studies in visceral leishmaniasis: identification of biomarkers for diagnostic, prognostic and drug target for treatment

A Kumar, SC Pandey, M Samant - Acta tropica, 2020 - Elsevier
Visceral leishmaniasis (VL) is one of the major infectious diseases affecting the poorest
regions of the world. Current therapy is not very much satisfactory. The alarming rise of drug …

The contribution of DNA microarray technology to gene expression profiling in Leishmania spp.: A retrospective view

A Alonso, V Larraga, PJ Alcolea - Acta Tropica, 2018 - Elsevier
The first completed genome project of any living organism, excluding viruses, was of the
gammaproteobacteria Haemophilus influenzae in 1995. Until the last decade, genome …

Molecular diagnosis of leishmaniasis

CAP Tavares, AP Fernandes… - Expert review of molecular …, 2003 - Taylor & Francis
This review describes the worldwide situation of visceral and tegumentary leishmaniasis
with an emphasis on diagnosis, including methods for the detection of antibodies, antigens …

Global gene expression in Leishmania

G Cohen-Freue, TR Holzer, JD Forney… - International journal for …, 2007 - Elsevier
The completion of the genomic sequences of many protozoan pathogens of humans,
including species of Leishmania, Trypanosoma and Plasmodium, provide new approaches …

Applications of molecular methods for Leishmania control

S Singh, A Dey, R Sivakumar - Expert review of molecular …, 2005 - Taylor & Francis
This article reviews the recent advances made in the field of human leishmaniasis. Special
emphasis is placed upon the application of various molecular tools for accurate and rapid …

Blood Transcriptional Profiling Reveals Immunological Signatures of Distinct States of Infection of Humans with Leishmania infantum

LG Gardinassi, GR Garcia, CHN Costa… - PLoS neglected …, 2016 - journals.plos.org
Visceral leishmaniasis (VL) can be lethal if untreated; however, the majority of human
infections with the etiological agents are asymptomatic. Using Illumina Bead Chip …

Alteration of the serum biomarker profiles of visceral leishmaniasis during treatment

MS Duthie, J Guderian, A Vallur, A Bhatia… - European journal of …, 2014 - Springer
Until recently, chemotherapy for visceral leishmaniasis (VL; also known as kala-azar) was
severely limited by factors such as high cost, route of administration, generation of side …

Transcriptome analysis during the process of in vitro differentiation of Leishmania donovani using genomic microarrays

G Srividya, R Duncan, P Sharma, BVS Raju… - Parasitology, 2007 - cambridge.org
Leishmania donovani causes visceral disease (kala-azar), a major health problem
throughout the tropics with 500 000 new cases every year. Leishmania differentiates from …

Molecular diagnosis of visceral leishmaniasis

S Sundar, OP Singh - Molecular diagnosis & therapy, 2018 - Springer
Visceral leishmaniasis (VL), a deadly parasitic disease, is a major public health concern
globally. Countries affected by VL have signed the London Declaration on Neglected …

Multi-omic analyses of plasma cytokines, lipidomics, and transcriptomics distinguish treatment outcomes in cutaneous leishmaniasis

H Malta-Santos, KF Fukutani, CA Sorgi, ATL Queiroz… - Iscience, 2020 - cell.com
Leishmania braziliensis infection frequently results in cutaneous leishmaniasis (CL). An
increase in incidence of drug-resistant CL leading to treatment failure has been reported …