Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era
Parkinson's disease (PD) is one of the most common neurodegenerative disorders that
manifest various motor and nonmotor symptoms. Although currently available therapies can …
manifest various motor and nonmotor symptoms. Although currently available therapies can …
Recent developments in nucleic acid-based therapies for Parkinson's disease: current status, clinical potential, and future strategies
Parkinson's disease is the second most common progressive neurodegenerative disease
diagnosed mainly based on clinical symptoms caused by loss of nigrostriatal dopaminergic …
diagnosed mainly based on clinical symptoms caused by loss of nigrostriatal dopaminergic …
The future of targeted gene-based treatment strategies and biomarkers in Parkinson's disease
A Polissidis, L Petropoulou-Vathi, M Nakos-Bimpos… - Biomolecules, 2020 - mdpi.com
Biomarkers and disease-modifying therapies are both urgent unmet medical needs in the
treatment of Parkinson's disease (PD) and must be developed concurrently because of their …
treatment of Parkinson's disease (PD) and must be developed concurrently because of their …
[HTML][HTML] Nucleic acid–based therapeutics for Parkinson's disease
M Nakamori, E Junn, H Mochizuki, MM Mouradian - Neurotherapeutics, 2019 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder that is diagnosed
largely on clinical grounds due to characteristic motor manifestations that result from the loss …
largely on clinical grounds due to characteristic motor manifestations that result from the loss …
Epigenetic biomarkers for Parkinson's disease: from diagnostics to therapeutics
JL Jakubowski, V Labrie - Journal of Parkinson's disease, 2017 - content.iospress.com
Parkinson's disease (PD) is a prevalent neurodegenerative illness that is often diagnosed
after significant pathology and neuronal cell loss has occurred. Biomarkers of PD are greatly …
after significant pathology and neuronal cell loss has occurred. Biomarkers of PD are greatly …
Precision medicine in Parkinson's disease: from genetic risk signals to personalized therapy
G Straccia, F Colucci, R Eleopra, R Cilia - Brain Sciences, 2022 - mdpi.com
Understanding the pathophysiology and genetic background of Parkinson's disease (PD)
increases the likelihood of developing effective disease-modifying therapeutic strategies. In …
increases the likelihood of developing effective disease-modifying therapeutic strategies. In …
Emerging roles of epigenetic mechanisms in Parkinson's disease
E Habibi, A Masoudi-Nejad, HM Abdolmaleky… - Functional & integrative …, 2011 - Springer
Epigenetic mechanisms have emerged as important components of a variety of human
diseases, including cancer and central nervous system disorders. Despite recent studies …
diseases, including cancer and central nervous system disorders. Despite recent studies …
[HTML][HTML] Molecular insights into Parkinson's disease
Parkinson's disease is a neurodegenerative movement disorder characterized by loss of
midbrain dopaminergic neurons leading to motor abnormalities and autonomic dysfunctions …
midbrain dopaminergic neurons leading to motor abnormalities and autonomic dysfunctions …
Human gene therapy approaches for the treatment of Parkinson's disease: An overview of current and completed clinical trials
Gene therapy has been employed in the human brain for a number of disorders in clinical
trials and may serve as an avenue for the treatment of Parkinson's disease (PD). Several …
trials and may serve as an avenue for the treatment of Parkinson's disease (PD). Several …
Role of genomics in translational research for Parkinson's disease
K Sekiyama, Y Takamatsu, M Waragai… - … and biophysical research …, 2014 - Elsevier
Research on Parkinson's disease (PD) has made remarkable progress in recent decades,
due largely to new genomic technologies, such as high throughput sequencing and …
due largely to new genomic technologies, such as high throughput sequencing and …
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