Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era

D Li, FL Mastaglia, S Fletcher… - Medicinal Research …, 2020 - Wiley Online Library
Parkinson's disease (PD) is one of the most common neurodegenerative disorders that
manifest various motor and nonmotor symptoms. Although currently available therapies can …

Recent developments in nucleic acid-based therapies for Parkinson's disease: current status, clinical potential, and future strategies

SK Pandey, RK Singh - Frontiers in Pharmacology, 2022 - frontiersin.org
Parkinson's disease is the second most common progressive neurodegenerative disease
diagnosed mainly based on clinical symptoms caused by loss of nigrostriatal dopaminergic …

The future of targeted gene-based treatment strategies and biomarkers in Parkinson's disease

A Polissidis, L Petropoulou-Vathi, M Nakos-Bimpos… - Biomolecules, 2020 - mdpi.com
Biomarkers and disease-modifying therapies are both urgent unmet medical needs in the
treatment of Parkinson's disease (PD) and must be developed concurrently because of their …

[HTML][HTML] Nucleic acid–based therapeutics for Parkinson's disease

M Nakamori, E Junn, H Mochizuki, MM Mouradian - Neurotherapeutics, 2019 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder that is diagnosed
largely on clinical grounds due to characteristic motor manifestations that result from the loss …

Epigenetic biomarkers for Parkinson's disease: from diagnostics to therapeutics

JL Jakubowski, V Labrie - Journal of Parkinson's disease, 2017 - content.iospress.com
Parkinson's disease (PD) is a prevalent neurodegenerative illness that is often diagnosed
after significant pathology and neuronal cell loss has occurred. Biomarkers of PD are greatly …

Precision medicine in Parkinson's disease: from genetic risk signals to personalized therapy

G Straccia, F Colucci, R Eleopra, R Cilia - Brain Sciences, 2022 - mdpi.com
Understanding the pathophysiology and genetic background of Parkinson's disease (PD)
increases the likelihood of developing effective disease-modifying therapeutic strategies. In …

Emerging roles of epigenetic mechanisms in Parkinson's disease

E Habibi, A Masoudi-Nejad, HM Abdolmaleky… - Functional & integrative …, 2011 - Springer
Epigenetic mechanisms have emerged as important components of a variety of human
diseases, including cancer and central nervous system disorders. Despite recent studies …

[HTML][HTML] Molecular insights into Parkinson's disease

B Thomas, MF Beal - F1000 medicine reports, 2011 - ncbi.nlm.nih.gov
Parkinson's disease is a neurodegenerative movement disorder characterized by loss of
midbrain dopaminergic neurons leading to motor abnormalities and autonomic dysfunctions …

Human gene therapy approaches for the treatment of Parkinson's disease: An overview of current and completed clinical trials

FL Hitti, AI Yang, P Gonzalez-Alegre… - Parkinsonism & related …, 2019 - Elsevier
Gene therapy has been employed in the human brain for a number of disorders in clinical
trials and may serve as an avenue for the treatment of Parkinson's disease (PD). Several …

Role of genomics in translational research for Parkinson's disease

K Sekiyama, Y Takamatsu, M Waragai… - … and biophysical research …, 2014 - Elsevier
Research on Parkinson's disease (PD) has made remarkable progress in recent decades,
due largely to new genomic technologies, such as high throughput sequencing and …