Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2
Abstract The Siah1 and Siah2 ubiquitin ligases are implicated in diverse biological
processes ranging from cellular stress responses, signaling to transcriptional regulation. A …
processes ranging from cellular stress responses, signaling to transcriptional regulation. A …
[HTML][HTML] The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription
Super elongation complexes (SECs) contain two different transcription elongation factors, P-
TEFb and ELL1/2, linked by the scaffolding protein AFF4 or AFF1. They stimulate the …
TEFb and ELL1/2, linked by the scaffolding protein AFF4 or AFF1. They stimulate the …
Eukaryotic translation elongation factor 1 delta inhibits the ubiquitin ligase activity of SIAH-1
H Wu, Y Shi, Y Lin, W Qian, Y Yu, K Huo - Molecular and cellular …, 2011 - Springer
Abstract SIAH-1, an E3 ubiquitin ligase, plays an important role in regulating cell cycle,
tumorigenesis and several neurodegenerative diseases. In this study, we found a novel …
tumorigenesis and several neurodegenerative diseases. In this study, we found a novel …
[HTML][HTML] The PARP1-Siah1 axis controls HIV-1 transcription and expression of Siah1 substrates
D Yu, R Liu, G Yang, Q Zhou - Cell reports, 2018 - cell.com
Recent studies have revealed a key role of PARP1 that catalyzes the poly-ADP-ribosylation
(PARylation) of substrates in regulating gene transcription. We show here that HIV-1 …
(PARylation) of substrates in regulating gene transcription. We show here that HIV-1 …
ELL-associated factors EAF1/2 negatively regulate HIV-1 transcription through inhibition of Super Elongation Complex formation
R Liu, C Chen, Y Li, Q Huang, Y Xue - Biochimica et Biophysica Acta (BBA) …, 2020 - Elsevier
Abstract The ELL (ELL1 and ELL2)-containing Super Elongation Complex (SEC) is required
for efficient HIV-1 transactivation by the viral-encoded Tat protein. EAF1 and EAF2 are ELL …
for efficient HIV-1 transactivation by the viral-encoded Tat protein. EAF1 and EAF2 are ELL …
DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes
Among all of the Super Elongation Complex (SEC) components, ELL1 (also known as ELL)
is the only bona fide elongation factor that directly stimulates transcription elongation by …
is the only bona fide elongation factor that directly stimulates transcription elongation by …
Super elongation complex promotes early HIV transcription and its function is modulated by P-TEFb
A Kuzmina, S Krasnopolsky, R Taube - Transcription, 2017 - Taylor & Francis
Early work on the control of transcription of the human immunodeficiency virus (HIV) laid the
foundation for our current knowledge of how RNA Polymerase II is released from promoter …
foundation for our current knowledge of how RNA Polymerase II is released from promoter …
[HTML][HTML] Investigating the molecular basis of Siah1 and Siah2 E3 ubiquitin ligase substrate specificity
A Gopalsamy, T Hagen, K Swaminathan - PloS one, 2014 - journals.plos.org
The Siah1 and Siah2 E3 ubiquitin ligases play an important role in diverse signaling
pathways and have been shown to be deregulated in cancer. The human Siah1 and Siah2 …
pathways and have been shown to be deregulated in cancer. The human Siah1 and Siah2 …
Regulators and effectors of Siah ubiquitin ligases
The Siah ubiquitin ligases are members of the RING finger E3 ligases. The Siah E3s are
conserved from fly to mammals. Primarily implicated in cellular stress responses, Siah …
conserved from fly to mammals. Primarily implicated in cellular stress responses, Siah …
The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and-independent pathways
J Qi, K Nakayama, S Gaitonde… - Proceedings of the …, 2008 - National Acad Sciences
The ubiquitin ligase Siah2 has been shown to regulate prolyl hydroxylase 3 (PHD3) stability
with concomitant effect on HIF-1α availability. Because HIF-1α is implicated in tumorigenesis …
with concomitant effect on HIF-1α availability. Because HIF-1α is implicated in tumorigenesis …