Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, typically
develops on the background of chronic liver disease and is an aggressive disease with …

Hepatocarcinogenesis involves complex genetic and cellular dysregulations which drive the
formation of hepatocellular carcinoma (HCC), the predominant form of primary liver cancer …

Tumor heterogeneity in hepatocellular carcinoma (HCC), such as that found in second
primary tumors after curative treatment, synchronous multifocal tumors of different clonality …

Hepatocellular carcinomas (HCCs) are highly heterogeneous malignancies with different
risk factors, including alcohol abuse, chronic hepatitis B virus (HBV) and hepatitis C virus …

Hepatocellular carcinoma (HCC) has one of the poorest survival rates among cancers.
Using multi-regional sampling of nine resected HCC with different aetiologies, here we …

Hepatocellular carcinoma (HCC) is one of the most prevalent and fatal digestive tumors.
Treatment for this disease has been constraint by heterogeneity of this group of tumors …

Background & Aims Intratumor molecular heterogeneity is a key feature of tumorigenesis
and is linked to treatment failure and patient prognosis. Herein, we aimed to determine what …

Hepatocellular carcinoma (HCC) is a cancer of substantial morphologic, genetic and
phenotypic diversity. Yet we do not understand the relationship between intratumor …

Background & Aims Human hepatocarcinogenesis is as a multi-step process starting from
dysplastic lesions to early carcinomas (eHCC) that ultimately progress to HCC (pHCC) …

Genomic analyses of primary liver cancer samples reveal a complex mutational landscape
with vast intertumor and intratumor heterogeneity. Different primary liver tumors and …