Background Postextubation high-flow nasal cannula (HFNC) is used as a support therapy in
high-risk patients in ICU. This study aimed to determine the effects of HFNC therapy on lung …

Background Optimal noninvasive respiratory support for patients with hypoxemic respiratory
failure should minimize work of breathing without increasing the transpulmonary pressure …

Background Timing of swallows in relation to respiratory phases is associated with
aspiration events. Oxygen therapy possibly affects the timing of swallows, which may alter …

Background Reintubation is associated with high mortality. Identification of methods to avoid
reintubation is needed. The aim of this study was to assess whether prophylactic …

Background The high-flow nasal cannula (HFNC) delivers up to 60 l/min of humidified
air/oxygen blend at a temperature close to that of the human body. In this study, we tested …

Introduction Alveolar derecruitment may occur during low tidal volume ventilation and may
be prevented by recruitment maneuvers (RMs). The aim of this study was to compare two …

Background There is very limited evidence identifying factors that increase respiratory drive
in hypoxemic intubated patients. Most physiological determinants of respiratory drive cannot …

Methods Inclusion criteria were mechanical ventilation for more than 24 hours and a
successful spontaneous breathing trial with PaO 2/FiO 2< 300 at the end of the trial …

Background Nasal high flow delivered at flow rates higher than 60 L/min in patients with
acute hypoxemic respiratory failure might be associated with improved physiological effects …

Background Dyspnea is a key symptom of de novo acute hypoxemic respiratory failure. This
study explores dyspnea and its association with intubation and mortality in this population …