Three Growth Factors Induce Proliferation and Differentiation of Neural Precursor Cells In Vitro and Support Cell‐Transplantation after Spinal Cord Injury In Vivo

A Younsi, G Zheng, M Scherer, L Riemann… - Stem Cells …, 2020 - Wiley Online Library
Stem cell therapy with neural precursor cells (NPCs) has the potential to improve
neuroregeneration after spinal cord injury (SCI). Unfortunately, survival and differentiation of …

Human embryonic stem cell-derived neural precursor transplants in collagen scaffolds promote recovery in injured rat spinal cord

M Hatami, NZ Mehrjardi, S Kiani, K Hemmesi, H Azizi… - …, 2009 - Taylor & Francis
Background aims Several studies have reported functional improvement after
transplantation of in vivo-derived neural progenitor cells (NPC) into injured spinal cord …

[HTML][HTML] A narrative review of advances in neural precursor cell transplantation therapies for spinal cord injury

T Kitagawa, N Nagoshi, H Okano, M Nakamura - Neurospine, 2022 - ncbi.nlm.nih.gov
A spinal cord injury (SCI) is a destructive event that causes a permanent deficit in
neurological function because of poor regenerative potential. Transplantation therapies …

[HTML][HTML] Neural stem/progenitor cells from the adult human spinal cord are multipotent and self-renewing and differentiate after transplantation

AJ Mothe, T Zahir, C Santaguida, D Cook, CH Tator - PloS one, 2011 - journals.plos.org
Neural stem/progenitor cell (NSPC) transplantation is a promising therapy for spinal cord
injury (SCI). However, little is known about NSPC from the adult human spinal cord as a …

[HTML][HTML] Endogenous neural progenitor cells in the repair of the injured spinal cord

Y Mao, T Nguyen, T Sutherland… - Neural regeneration …, 2016 - journals.lww.com
Stem cell treatments, and in particular, stem cell transplants have been identified as
potential therapeutic strategies for a range of neurodegenerative and acquired conditions of …

Improving the therapeutic efficacy of neural progenitor cell transplantation following spinal cord injury

MA Lane, AC Lepore, I Fischer - Expert review of neurotherapeutics, 2017 - Taylor & Francis
Introduction: There have been a wide range of preclinical studies testing cellular therapies to
repair the injured spinal cord, yet they remain a challenge to translate because of …

Early response of endogenous adult neural progenitor cells to acute spinal cord injury in mice

Y Ke, L Chi, R Xu, C Luo, D Gozal, R Liu - Stem cells, 2006 - academic.oup.com
Adult neural progenitor cells (NPCs) are an attractive source for functional replacement in
neurodegenerative diseases and traumatic injury to the central nervous system (CNS). It has …

Transplanted neural progenitor cells survive and differentiate but achieve limited functional recovery in the lesioned adult rat spinal cord

DJ Webber, EJ Bradbury, SB McMahon… - Regenerative …, 2007 - Taylor & Francis
Endogenous repair after injury in the adult CNS is limited by a number of factors including
cellular loss, inflammation, cavitation and glial scarring. Spinal cord neural progenitor cells …

[HTML][HTML] Adult neural progenitor cells transplanted into spinal cord injury differentiate into oligodendrocytes, enhance myelination, and contribute to recovery

SR Sankavaram, R Hakim, R Covacu, A Frostell… - Stem Cell Reports, 2019 - cell.com
Long-term survival and integration of neural progenitor cells (NPCs) transplanted following
spinal cord injury (SCI) have been observed. However, questions concerning the …

The application of neural stem/progenitor cells for regenerative therapy of spinal cord injury

C Yu, K Xia, Z Gong, L Ying, J Shu… - Current stem cell …, 2019 - ingentaconnect.com
Spinal cord injury (SCI) is a devastating event, and there are still no effective therapies
currently available. Neural stem cells (NSCs) have gained increasing attention as promising …