Lysosomes are of major importance for the regulation of cellular cholesterol homeostasis.
Food-derived cholesterol and cholesterol esters contained within lipoproteins are delivered …

The intracellular transport of cholesterol is subject to tight regulation. The structure of the
lysosomal integral membrane protein type 2 (LIMP-2, also known as SCARB2) reveals a …

Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of
cells and organisms. Cells rely on a sophisticated but poorly understood network of …

Lipoprotein cholesterol taken up by cells is processed in the endosomal/lysosomal (E/L)
compartment by the sequential action of lysosomal acid lipase (LAL), Niemann-Pick C2 …

Egress of lipoprotein-derived cholesterol from lysosomes requires two lysosomal proteins,
polytopic membrane-bound Niemann–Pick C1 (NPC1) and soluble Niemann–Pick C2 …

Summary Water-soluble Niemann-Pick C2 (NPC2) and membrane-bound NPC1 are
cholesterol-binding lysosomal proteins required for export of lipoprotein-derived cholesterol …

The function of lysosomes relies on the ability of the lysosomal membrane to fuse with
several target membranes in the cell. It is known that in lysosomal storage disorders (LSDs) …

The mechanisms of endosomal and lysosomal cholesterol traffic are still poorly understood.
We showed previously that unesterified cholesterol accumulates in the late endosomes and …

The Niemann-Pick C1 (NPC1) protein and endocytosed low density lipoprotein (LDL)-
derived cholesterol were shown to enrich separate subsets of vesicles containing lysosomal …

LAMP1 and LAMP2 proteins are highly abundant, ubiquitous, mammalian proteins that line
the lysosome limiting membrane, and protect it from lysosomal hydrolase action. LAMP2 …