α-Synuclein amyloid aggregation is a defining molecular feature of Parkinson's disease,
Lewy body dementia, and multiple system atrophy, but can also be found in other …

Despite attracting the close attention of multiple researchers for the past 25 years, α-
synuclein continues to be an enigma, hiding sacred truth related to its structure, function …

Oligomeric forms of amyloid aggregates have been detected in the brains and tissues of
patients suffering from neurodegenerative disorders such as Parkinson's disease, and it is …

Biochemcal and genetic evidence point towards α-synuclein aggregation as having a pivotal
role in the onset and progression of several neurodegenerative disorders, including …

Parkinson's disease is the second most common neurodegenerative disease, and results
from loss of dopaminergic neurons in the substantia nigra. The aggregation and fibrillation of …

Aggregated a-synuclein is the major component of inclusions in Parkinson's disease and
other synucleinopathy brains indicating that a-syn aggregation is associated with the …

In the past few years, an increasing amount of studies primarily based on experimental
models have investigated the existence of distinct α-synuclein strains and their different …

Accumulation of the neuronal presynaptic protein alpha-synuclein within proteinaceous
inclusions represents the key histophathological hallmark of a spectrum of …

α-Synuclein is an abundant presynaptic brain protein, misfolding, aggregation and
fibrillation of which are implicated as critical factors in several neurodegenerative diseases …

The synucleinopathies, which include Parkinson's disease, dementia with Lewy bodies, and
multiple system atrophy, are a class of human neurodegenerative disorders unified by the …