Pharmacometric methods have hugely benefited from progress in analytical and computer
sciences during the past decades, and play nowadays a central role in the clinical …

The therapeutic activity of drugs can be optimized by establishing an individualized dosage,
based on the measurement of the drug concentration in the serum, particularly if the drugs …

Therapeutic drug monitoring (TDM) can be defined as the measurement of drug in biological
samples to individualise treatment by adapting drug dose to improve efficacy and/or reduce …

Imatinib, also known as Gleevec® or Glivec®, is a selective tyrosine kinase inhibitor
currently used for the treatment of Philadelphia chromosome-positive chronic myeloid …

Purpose This study assessed whether a cycle of “routine” therapeutic drug monitoring (TDM)
for imatinib dosage individualization, targeting an imatinib trough plasma concentration (C …

Background The imatinib trough plasma concentration (C min) correlates with clinical
response in cancer patients. Therapeutic drug monitoring (TDM) of plasma C min is …

Most of oral targeted therapies are tyrosine kinase inhibitors (TKIs). Oral administration
generates a complex step in the pharmacokinetics (PK) of these drugs. Inter-individual PK …

Background: Correlation analyses have demonstrated that maintaining an adequate
imatinib (IM) trough concentration would be important for clinical response in patients with …

Although therapeutic drug monitoring (TDM) is an important tool in guiding drug dosing for
other areas of medicine including infectious diseases, cardiology, psychiatry and transplant …

This study set out to examine in a large real‐life cohort of patients with chronic myeloid
leukemia (CML) the impact of imatinib threshold of 1000 ng/mL on molecular response, as …