Airway-on-a-Chip: Development and in Vitro Validation of a Microfluidic Cell Culture Model for Chronic Obstructive Pulmonary Disease
TJ Bennet, B Shen, J Siwik, S Pan… - 2020 IEEE 33rd …, 2020 - ieeexplore.ieee.org
We report a microfluidic cell culture model that incorporates a novel 3-dimensional
extracellular matrix composed of a biodegradable membrane and lumen-patterned, cell …
extracellular matrix composed of a biodegradable membrane and lumen-patterned, cell …
Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions
Chronic lung diseases (CLDs) are regulated by complex interactions between many
different cell types residing in lung airway tissues. Specifically, interactions between airway …
different cell types residing in lung airway tissues. Specifically, interactions between airway …
A 96-well format microvascularized human lung-on-a-chip platform for microphysiological modeling of fibrotic diseases
Development of organoids and microfluidic on-chip models has enabled studies of organ-
level disease pathophysiologies in vitro. However, current lung-on-a-chip platforms are …
level disease pathophysiologies in vitro. However, current lung-on-a-chip platforms are …
A novel Organ-Chip system emulates three-dimensional architecture of the human epithelia and allows fine control of mechanical forces acting on it.
A Varone, JK Nguyen, L Leng, R Barrile, J Sliz… - bioRxiv, 2020 - biorxiv.org
Successful translation of in vivo experimental data to human patients is an unmet need and
a bottleneck in the development of effective therapeutics. micro technology aims to address …
a bottleneck in the development of effective therapeutics. micro technology aims to address …
Organ-on-chip meets immunology: let's start with the lungs
KH Benam - The Journal of Immunology, 2020 - journals.aai.org
Organs-on-chips are biomimetic, microfluidic, cell culture devices created with microchip
manufacturing methods that contain continuously perfused hollow microchannels inhabited …
manufacturing methods that contain continuously perfused hollow microchannels inhabited …
A lung-on-a-chip array with an integrated bio-inspired respiration mechanism
We report a lung-on-a-chip array that mimics the pulmonary parenchymal environment,
including the thin alveolar barrier and the three-dimensional cyclic strain induced by …
including the thin alveolar barrier and the three-dimensional cyclic strain induced by …
Human lung small airway-on-a-chip protocol
Organs-on-chips are microfluidic cell culture devices created using microchip manufacturing
techniques that contain hollow microchannels lined by living cells, which recreate …
techniques that contain hollow microchannels lined by living cells, which recreate …
Airflow-Mediated Microfluidic Device for Culturing Lung Airway Cells on a Suspended Hydrogel
S Park - 2023 - search.proquest.com
Airway epithelial cells (AECs) are a crucial component of the lung airways, responsible for
safeguarding our respiratory health by defending against inhaled particles like bacteria …
safeguarding our respiratory health by defending against inhaled particles like bacteria …
Microfabrication of human organs-on-chips
Abstract'Organs-on-chips' are microengineered biomimetic systems containing microfluidic
channels lined by living human cells, which replicate key functional units of living organs to …
channels lined by living human cells, which replicate key functional units of living organs to …
[HTML][HTML] A bioinspired microfluidic model of liquid plug-induced mechanical airway injury
Occlusion of distal airways due to mucus plugs is a key pathological feature common to a
wide variety of obstructive pulmonary diseases. Breathing-induced movement of airway …
wide variety of obstructive pulmonary diseases. Breathing-induced movement of airway …