There is a persistent, aberrant accumulation of V0/V1 versican in skeletal muscles from
patients with Duchenne muscular dystrophy and in diaphragm muscles from mdx mice …

In Duchenne muscular dystrophy (DMD), a dysregulated extracellular matrix (ECM) directly
exacerbates pathology. Glucocorticoids are beneficial therapeutics in DMD, and have …

Aberrant extracellular matrix synthesis and remodeling contributes to muscle degeneration
and weakness in Duchenne muscular dystrophy (DMD). ADAMTS-5, a secreted …

Versican is a proteoglycan that has many different roles in tissue homeostasis and
inflammation. The biochemical structure comprises four different types of the core protein …

Abstract Duchenne Muscular Dystrophy (DMD) is caused by mutations in the dystrophin
gene, accompanied by aberrant extracellular matrix synthesis and muscle damage …

Background Duchenne muscular dystrophy (DMD) is a fatal muscle‐wasting disorder
caused by genetic loss of dystrophin protein. Extracellular microRNAs (ex‐miRNAs) are …

Skeletal muscle development and regeneration requires the fusion of myoblasts into
multinucleated myotubes. Because the enzymatic proteolysis of a hyaluronan and versican …

Cardiac fibrosis is a central pathological feature in several cardiac diseases, but the
underlying molecular players are insufficiently understood. The extracellular matrix …

Duchenne muscular dystrophy (DMD) is a rare genetic disease leading to progressive
muscle wasting, respiratory failure, and cardiomyopathy. Although muscle fibrosis …

Duchenne muscular dystrophy (DMD) is a fatal muscle-wasting disorder caused by
mutations in the Dystrophin gene and for which there is currently no cure. To bridge the gap …