Central action of the adipocyte hormone leptin via the neuropeptide Y (NPY) system is
considered critical for energy homeostatic control. However, the precise mechanisms for this …

Objective One of leptin's main targets in the hypothalamus are neuropeptide Y (NPY)
neurons, with selective deletion of leptin receptors (Lepr) specifically in Npy neurons …

Neuropeptide Y (NPY) in the arcuate nucleus (ARC) is known as one of the most critical
regulators of feeding. However, how NPY promotes feeding under obese conditions is …

Leptin is an adipocytokine that circulates in proportion to body fat to signal the repletion of
long-term energy stores. Leptin acts via its receptor, LepRb, on specialized neuronal …

Evidence shows that neuropeptide Y (NPY) neurons are involved in mediating the
anorexigenic action of leptin via neuronal circuits in the hypothalamus. However, studies …

The increasing incidence of obesity and obesity-linked disease presents a serious global
health threat. To develop truly effective therapies to modulate food intake and promote …

Two known types of leptin-responsive neurons reside within the arcuate nucleus: the agouti
gene-related peptide (AgRP)/neuropeptide Y (NPY) neuron and the proopiomelanocortin …

Background/objectives Maintaining energy balance is important to ensure a healthy
organism. However, energy partitioning, coordinating the distribution of sufficient energy to …

Neuropeptide Y (NPY) neurons in both the arcuate nucleus of the hypothalamus (ARH) and
the dorsomedial hypothalamus (DMH) have been implicated in food intake and obesity …

Leptin signals the repletion of fat stores, acting in the CNS to permit energy utilization by a
host of autonomic and neuroendocrine processes and to decrease feeding. While much …