Cancer cells are characterized by quick growth and proliferation, demanding constant
supply of various nutrients. Several plasma membrane transporters delivering such …

Tumor cells have an increased demand for glucose and amino acids to support their rapid
growth, and also exhibit alterations in biochemical pathways that metabolize these nutrients …

Amino acids are indispensable nutrients for both normal and cancer cells. Cancer cells are
unable to synthesize essential amino acids as well as some non‐essential amino acids …

Amino acids are essential building blocks of all mammalian cells, and amino acid
transporters play a vital role in transporting them into cells and their further distribution …

SLC6A14, also known as ATB 0,+, is an amino acid transporter with unique characteristics. It
transports 18 of the 20 proteinogenic amino acids. However, this transporter is expressed …

Cancer cells require a massive supply of nutrients, including sugars and amino acids—the
upregulation of transporters for each nutrient contributes to meet the demand. Distinct from …

SLC6A14 (ATB0,+) is a sodium-and chloride-dependent neutral and dibasic amino acid
transporter that regulates the distribution of amino acids across cell membranes. The …

Background: The solute carrier family 7 (SLC7) can be categorically divided into two
subfamilies, the L-type amino acid transporters (LATs) including SLC7A5-13, and SLC7A15 …

Rapidly proliferating cancer cells increase flux through anabolic pathways to build the mass
necessary to support cell division. Imported amino acids and glucose lie at the apex of the …

Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are
highly dependent on nutrients in order to duplicate their cell mass during each cell division …