For long time bilirubin was only considered as a potentially dangerous sign of liver diseases,
but it now appears clear that it is also a powerful signaling molecule. Together with potent …

Bilirubin has several physiological functions, both beneficial and harmful. In addition to
reactive oxygen species-scavenging activities, bilirubin has potent immunosuppressive …

Bilirubin belongs to a phylogenetically old superfamily of tetrapyrrolic compounds, which
have multiple biological functions. Although for decades bilirubin was believed to be only a …

Recent research on bilirubin, a historically well-known waste product of heme catabolism,
suggests an entirely new function as a metabolic hormone that drives gene transcription by …

Bilirubin is a tetrapyrrolic compound originating from heme catabolism. Although originally
considered only a potentially dangerous waste product, it has become increasingly evident …

Unconjugated bilirubin (UCB) is known to be one of the most potent endogenous antioxidant
substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver …

Bilirubin is a potent antioxidant but can be toxic at high concentrations. This article critically
reviews the reported relationships of plasma bilirubin levels to the severity and/or incidence …

There is strong evidence that serum free bilirubin concentration has significant effects on
morbidity and mortality in the most significant health conditions of our times, including …

Bilirubin, the principal tetrapyrrole, bile pigment and catabolite of haem, is an emerging
biomarker of disease resistance, which may be related to several recently documented …

Nearly a century ago, jaundiced patients were observed to have surprising and
spontaneous remissions from incurable immunologic diseases including rheumatoid …