Protective ventilation strategies for the injured lung currently revolve around the use of low
Vt, ostensibly to avoid volutrauma, together with positive end-expiratory pressure to increase …

Mechanical ventilation can produce lung physiological and morphological alterations
termed ventilator-induced lung injury (VILI). Early experimental studies demonstrated that …

The pathophysiological mechanisms by which mechanical ventilation can contribute to lung
injury, termed “ventilator-induced lung injury”(VILI), is increasingly well understood.“ …

Despite over 40 years of research, there is no specific lung-directed therapy for the acute
respiratory distress syndrome (ARDS). Although much has evolved in our understanding of …

As with most medical and pharmacologic interventions, mechanical ventilation must be
titrated within a therapeutic window, providing the required lifesustaining support while …

Ventilator-induced lung injury (VILI) results from injury to the blood-gas barrier caused by
mechanical ventilation. The determinants of VILI are more complex than originally thought …

The last two decades have brought new insights into mechanisms of lung injury. These
insights have profoundly altered the ventilator management of patients with adult respiratory …

Once upon a time the existence of ventilator-induced lung injury (VILI) was debated. After all,
most patients with lung dysfunction requiring mechanical ventilation had other potential …

Ventilator-induced lung injury (VILI) is a central confounder to improving outcomes from use
of positive-pressure ventilation in critical illness. Therefore, with increasing use of positive …

It may be hard to argue against the thesis that mechanical ventilation represents one of the
most important treatments ever introduced in the care of patients with respiratory failure …