Background: Hypertension is a common modifiable risk factor for cardiovascular disease
and mortality. Pathophysiological mechanisms leading to hypertension remain incompletely …

Hypertension (HTN) is a frequent condition with multifactorial cause in which genetic, fetal
and environmental factors interact to result in the final phenotype of blood pressure (BP) …

Background The causal relevance of elevated blood pressure for several cardiovascular
diseases (CVDs) is uncertain, as is the population impact of blood pressure lowering. This …

Hypertension is a major risk factor for cardiovascular disease and mortality. To identify
targets for the prevention of hypertension and its associated disease burden, we used the 2 …

Background: Cardiovascular diseases (CVD) remain the leading cause of death worldwide,
while a lack of clarity on underlying mechanisms has hindered development of novel …

This study aims to evaluate the causal association of blood pressure (BP) with
cardiovascular diseases (CVDs). Two-sample Mendelian randomization was performed …

Observational studies exploring whether there is a nonlinear effect of blood pressure on
cardiovascular disease (CVD) risk are hindered by confounding. This limitation can be …

Circulating biomarkers play a pivotal role in personalized medicine, offering potential for
disease screening, prevention, and treatment. Despite established associations between …

A true discrepancy between the effect of systolic blood pressure (SBP) and diastolic blood
pressure (DBP) on cardiovascular (CV) outcomes remains unclear. This study performed …

Among the common complex diseases, hypertension has been particularly unlucky in the
recent surge of positive results from genome-wide association studies. We summarize the …