Erectile dysfunction (ED) is a prevalent condition, especially in men over 40 years old,
characterized by the inability to obtain and/or maintain penile erection sufficient for …

The incidence of erectile dysfunction (ED), defined as the persistent inability to achieve or
maintain an erection sufficient for satisfactory sexual performance, increases with age and …

Background and purpose: Large‐conductance Ca2+‐activated K+ channels (BKCa), located
on the arterial and corporal smooth muscle, are potential targets for treatment of erectile …

Modulation of endothelial calcium-activated K+ channels has been proposed as an
approach to restore arterial endothelial cell function in disease. We hypothesized that small …

Introduction Recent electrophysiological recordings have identified the existence of outward,
excitatory chloride (Cl−) currents in rat, rabbit, and human corpus cavernosum (CC) muscle …

Normal erectile function is a complex neurovascular process that is dependent on a delicate
balance between the effects of endogenous vasoconstrictor and vasorelaxing agents on the …

The corporal myocyte is a critical determinant of erectile capacity whose functional integrity,
in the vast majority of impotent patients, is sufficient to guarantee its relevance as a …

Introduction Nitric oxide–cyclic guanosine monophosphate (NO–cGMP)–mediated
relaxation of cavernosal smooth muscle during erection is accompanied by a decrease in …

Penile erection is dependent on the nitric oxide (NO)/cGMP‐dependent protein kinase I
(PKGI) pathway. One important target of PKGI in smooth muscle is the large‐conductance …

Background Activation of endothelial small conductance calcium-activated K+ channels
(KCa2. 3) and intermediate conductance calcium-activated K+ channels (KCa3. 1) leads to …