Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth
While a genetic component of preterm birth (PTB) has long been recognized and recently
mapped by genome-wide association studies (GWASs), the molecular determinants …
mapped by genome-wide association studies (GWASs), the molecular determinants …
Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm
Background Human pluripotent stem cells offer the best available model to study the
underlying cellular and molecular mechanisms of human embryonic lineage specification …
underlying cellular and molecular mechanisms of human embryonic lineage specification …
Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells
Measuring gene expression in individual cells is crucial for understanding the gene
regulatory network controlling human embryonic development. Here we apply single-cell …
regulatory network controlling human embryonic development. Here we apply single-cell …
Gene expression signatures defining fundamental biological processes in pluripotent, early, and late differentiated embryonic stem cells
Investigating the molecular mechanisms controlling the in vivo developmental program
postembryogenesis is challenging and time consuming. However, the developmental …
postembryogenesis is challenging and time consuming. However, the developmental …
ESCAPE: database for integrating high-content published data collected from human and mouse embryonic stem cells
High content studies that profile mouse and human embryonic stem cells (m/hESCs) using
various genome-wide technologies such as transcriptomics and proteomics are constantly …
various genome-wide technologies such as transcriptomics and proteomics are constantly …
[HTML][HTML] Cross-species transcriptional profiles establish a functional portrait of embryonic stem cells
Y Sun, H Li, Y Liu, S Shin, MP Mattson, MS Rao… - Genomics, 2007 - Elsevier
An understanding of the regulatory mechanisms responsible for pluripotency in embryonic
stem cells (ESCs) is critical for realizing their potential in medicine and science. Significant …
stem cells (ESCs) is critical for realizing their potential in medicine and science. Significant …
Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity
Large-scale gene expression profiling was performed on embryo-derived stem cell lines to
identify molecular signatures of pluripotency and lineage specificity. Analysis of pluripotent …
identify molecular signatures of pluripotency and lineage specificity. Analysis of pluripotent …
[PDF][PDF] Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast
Single-cell profiling techniques create opportunities to delineate cell fate progression in
mammalian development. Recent studies have provided transcriptome data from human pre …
mammalian development. Recent studies have provided transcriptome data from human pre …
Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy
Growth and survival of the mammalian embryo within the uterine environment depends on
the placenta, a highly complex vascularized organ comprised of both maternal and foetal …
the placenta, a highly complex vascularized organ comprised of both maternal and foetal …
Mapping gene circuits essential for germ layer differentiation via loss-of-function screens in haploid human embryonic stem cells
A Yilmaz, C Braverman-Gross, A Bialer-Tsypin… - Cell Stem Cell, 2020 - cell.com
Pluripotent stem cells can differentiate into all embryonic germ layers, yet the genes
essential for these cell fate transitions in human remain elusive. Here, we mapped the …
essential for these cell fate transitions in human remain elusive. Here, we mapped the …