Background The presence of foamy macrophages and microglia containing intracellular
myelin remnants is a pathological hallmark of neurodegenerative disorders such as multiple …

Microglial activation during neuroinflammation is crucial for coordinating the immune
response against neuronal tissue, and the initial response of microglia determines the …

Infiltrating monocyte-derived macrophages (MM Φ) influence stroke-induced brain injury.
Although the inflammatory nature of MM Φ in acute stroke has been well documented, their …

Background Traumatic injury to axons produces breakdown of axons and myelin at the site
of the lesion and then further distal to this where Wallerian degeneration develops. The …

Inflammation is an essential component for glial scar formation. However, the upstream
mediator (s) that triggers the process has not been identified. Previously, we showed that the …

Genome‐wide association studies demonstrated that polymorphisms in the CD33/sialic acid‐
binding immunoglobulin‐like lectin 3 gene are associated with late‐onset Alzheimer's …

CD36 is a membrane protein with wide distribution in the human body, is enriched in the
monocyte-macrophage system and endothelial cells, and is involved in the cellular uptake of …

Reactive macrophages/microglia exert both protective or damaging effects in multiple
sclerosis (MS), which contribute to the relapsing–remitting nature of MS. CD163 is …

Background Immune activation, specifically activation of macrophages and resident
microglia, leading to inflammation is a key component in the progression of spinal cord …

Multiple sclerosis (MS) is pathologically characterized by inflammatory demyelination and
neuronal injury. Although phagocytosis of myelin debris by microglia and macrophages in …