Bipolar disorder (BD) has been associated with clinical signs of accelerated aging, which
potentially underlies its association with several age-related medical conditions, such as …

Bipolar Disorder (BD) has been conceptualized as both a cyclic and a progressive disorder.
Mechanisms involved in neuroprogression in BD remain largely unknown although several …

Objectives Evidence suggests accelerated aging mechanisms in bipolar disorder (BD),
including DNA methylation (DNAm) aging in blood. However, it is unknown whether such …

Bipolar disorder (BD) has been previously associated with accelerated aging; yet, the
mechanisms underlying this association are largely unknown. The epigenetic clock has …

Background: Growing evidence supports the existence of neurobiological trait abnormalities
in individuals at genetic risk for bipolar disorder. The aim of this study was to examine …

Background Bipolar disorder (BD) is associated with a reduced life expectancy compared to
the general population mainly due to a high prevalence of comorbid somatic illnesses. A …

Abstract The 10–15-years decrease in life expectancy observed in individuals with bipolar
disorder (BD) has been linked to the concept of accelerated cellular aging. Telomere length …

Objectives In the coming generation, older adults with bipolar disorder (BD) will increase in
absolute numbers as well as proportion of the general population. This is the first report of …

There is high mortality among patients with bipolar disorder (BD). Studies have reported
accelerated biological aging in patients with BD. Recently, Horvath and Hannum et al …

There is now strong evidence of progressive neuropathological processes in bipolar
disorder (BD). On this basis, the current understanding of the neurobiology of BD has shifted …