All the energy that is required by the body to perform its daily functions is supplied by the
nutrients present in food; thus, these nutrients should be readily available. However, food …

Nuclear receptors are master regulators of energy metabolism through the conversion of
extracellular signals into gene expression signatures. The function of the respective nuclear …

Research efforts focusing on metabolic diseases have established a close conjunction
between glucolipid abnormalities and nuclear receptors, a large superfamily of receptors …

The Nuclear Receptors in Liver and Digestive Diseases research workshop was held in
Rockville, Maryland, on November 7 and 8, 2007, under the auspices of the National …

▪ Abstract The metabolic nuclear receptors act as metabolic and toxicological sensors,
enabling the organism to quickly adapt to environmental changes by inducing the …

Obesity causes excess fat accumulation in various tissues, most notoriously in the adipose
tissue, along with other insulin‐responsive organs such as skeletal muscle and the liver …

Today, we are witnessing a rising incidence of obesity worldwide. This increase is due to a
sedentary life style, an increased caloric intake and a decrease in physical activity. Obesity …

Nuclear hormone receptors are found at the heart of virtually every biological process. In
addition to their functions in mediating steroid hormone effects, the role of this superfamily in …

Altered regulation of energy metabolism is the hallmark of many diseases that have a
significant burden of cardiovascular events. Diabetes, metabolic syndrome, and …

Nuclear receptors (NR) are transcription factors that are regulated by ligand binding. Several
members of this family regulate glucose and lipid metabolism in vivo and consequently play …