The pathogenesis of diabetic kidney disease is a complex process caused by both
glucotoxicity and lipotoxicity due to lipid accumulation. In cases of diabetic animals, lipid …

Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from
adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin …

Role of lipid control in diabetic nephropathy. Patients with diabetic nephropathy are known
to be associated with many lipoprotein abnormalities, including higher plasma levels of very …

Although several factors may mediate the development and progression of diabetic
nephropathy, hyperlipidemia is now considered an independent and major determinant of …

Although diabetes is mainly diagnosed based on elevated glucose levels, dyslipidemia is
also observed in these patients. Chronic kidney disease (CKD), a frequent occurrence in …

Lipotoxicity is the dysregulation of the lipid environment and/or intracellular composition that
leads to accumulation of harmful lipids and ultimately to organelle dysfunction, abnormal …

Studies of renal injury III: Lipid-induced nephropathy in type II diabetes Background
Nephrotoxicity from elevated circulating lipids occurs in experimental and clinical situations …

In the last few decades, rapid changes in lifestyle have led to an alarming increase in the
prevalence of obesity and obesity-associated complications. Obese patients are at …

Cellular toxicity mediated by lipids (lipotoxicity) has been implicated in the pathophysiology
of metabolic syndrome and diabetes mellitus. Genetic analyses now implicate lipotoxicity in …

Lipotoxicity is a fundamental pathophysiologic mechanism in diabetes and non-alcoholic
fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) …