Renal lipid metabolism and lipotoxicity in diabetes
L Thongnak, A Pongchaidecha… - The American journal of the …, 2020 - Elsevier
The pathogenesis of diabetic kidney disease is a complex process caused by both
glucotoxicity and lipotoxicity due to lipid accumulation. In cases of diabetic animals, lipid …
glucotoxicity and lipotoxicity due to lipid accumulation. In cases of diabetic animals, lipid …
Lipotoxicity and diabetic nephropathy: novel mechanistic insights and therapeutic opportunities
L Opazo-Ríos, S Mas, G Marín-Royo… - International journal of …, 2020 - mdpi.com
Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from
adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin …
adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin …
[HTML][HTML] Role of lipid control in diabetic nephropathy
HC Chen, JY Guh, JM Chang, MC Hsieh, SJ Shin… - Kidney International, 2005 - Elsevier
Role of lipid control in diabetic nephropathy. Patients with diabetic nephropathy are known
to be associated with many lipoprotein abnormalities, including higher plasma levels of very …
to be associated with many lipoprotein abnormalities, including higher plasma levels of very …
Lipids and diabetic nephropathy
RF Rosario, S Prabhakar - Current diabetes reports, 2006 - Springer
Although several factors may mediate the development and progression of diabetic
nephropathy, hyperlipidemia is now considered an independent and major determinant of …
nephropathy, hyperlipidemia is now considered an independent and major determinant of …
The evolving understanding of the contribution of lipid metabolism to diabetic kidney disease
K Stadler, IJ Goldberg, K Susztak - Current diabetes reports, 2015 - Springer
Although diabetes is mainly diagnosed based on elevated glucose levels, dyslipidemia is
also observed in these patients. Chronic kidney disease (CKD), a frequent occurrence in …
also observed in these patients. Chronic kidney disease (CKD), a frequent occurrence in …
[HTML][HTML] The role of lipotoxicity in kidney disease: from molecular mechanisms to therapeutic prospects
L Ren, H Cui, Y Wang, F Ju, Y Cai, X Gang… - Biomedicine & …, 2023 - Elsevier
Lipotoxicity is the dysregulation of the lipid environment and/or intracellular composition that
leads to accumulation of harmful lipids and ultimately to organelle dysfunction, abnormal …
leads to accumulation of harmful lipids and ultimately to organelle dysfunction, abnormal …
[HTML][HTML] Studies of renal injury III: lipid-induced nephropathy in type II diabetes
JH Dominguez, N Tang, W Xu, AP Evan, AN Siakotos… - Kidney international, 2000 - Elsevier
Studies of renal injury III: Lipid-induced nephropathy in type II diabetes Background
Nephrotoxicity from elevated circulating lipids occurs in experimental and clinical situations …
Nephrotoxicity from elevated circulating lipids occurs in experimental and clinical situations …
Lipotoxicity as a trigger factor of renal disease
A Izquierdo-Lahuerta, C Martínez-García… - Journal of …, 2016 - Springer
In the last few decades, rapid changes in lifestyle have led to an alarming increase in the
prevalence of obesity and obesity-associated complications. Obese patients are at …
prevalence of obesity and obesity-associated complications. Obese patients are at …
Lipotoxicity in diabetic nephropathy: the potential role of fatty acid oxidation
M Murea, BI Freedman, JS Parks… - Clinical Journal of the …, 2010 - journals.lww.com
Cellular toxicity mediated by lipids (lipotoxicity) has been implicated in the pathophysiology
of metabolic syndrome and diabetes mellitus. Genetic analyses now implicate lipotoxicity in …
of metabolic syndrome and diabetes mellitus. Genetic analyses now implicate lipotoxicity in …
The contribution of lipotoxicity to diabetic kidney disease
JR Schelling - Cells, 2022 - mdpi.com
Lipotoxicity is a fundamental pathophysiologic mechanism in diabetes and non-alcoholic
fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) …
fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) …