The role of circulating tumor cells in the metastatic cascade: biology, technical challenges, and clinical relevance

H Dianat-Moghadam, M Azizi, Z Eslami-S… - Cancers, 2020 - mdpi.com
Metastases and cancer recurrence are the main causes of cancer death. Circulating Tumor
Cells (CTCs) and disseminated tumor cells are the drivers of cancer cell dissemination. The …

Circulating tumor cells: from basic to translational research

LE Cortés-Hernández, Z Eslami-S, K Pantel… - Clinical …, 2024 - academic.oup.com
Background Metastasis is the leading cause of cancer-related deaths. Most studies have
focused on the primary tumor or on overt metastatic lesions, leaving a significant knowledge …

Circulating tumor cells (CTCs): a unique model of cancer metastases and non-invasive biomarkers of therapeutic response

J Liu, J Lian, Y Chen, X Zhao, CZ Du, Y Xu, H Hu… - Frontiers in …, 2021 - frontiersin.org
Late-stage cancer metastasis remains incurable in the clinic and is the major cause death in
patients. Circulating tumor cells (CTCs) are thought to be metastatic precursors shed from …

Early dissemination of circulating tumor cells: biological and clinical insights

F Chemi, S Mohan, T Guevara, A Clipson… - Frontiers in …, 2021 - frontiersin.org
Circulating tumor cells (CTCs) play a causal role in the development of metastasis, the major
cause of cancer-associated mortality worldwide. In the past decade, the development of …

Looking back, to the future of circulating tumor cells

TW Friedlander, G Premasekharan, PL Paris - Pharmacology & therapeutics, 2014 - Elsevier
Detection and analysis of circulating tumor cells (CTCs) from patients with metastatic
malignancies have become active areas of research in recent years. CTC enumeration has …

Circulating tumor cells as “liquid biopsies” to understand cancer metastasis

D Woo, M Yu - Translational research, 2018 - Elsevier
Circulating tumor cells (CTCs) are a subset of cancer cells that are shed from the primary or
metastatic tumors into the bloodstream. CTCs are responsible for the establishment of blood …

Biology, detection, and clinical implications of circulating tumor cells

SA Joosse, TM Gorges, K Pantel - EMBO molecular medicine, 2015 - embopress.org
Cancer metastasis is the main cause of cancer‐related death, and dissemination of tumor
cells through the blood circulation is an important intermediate step that also exemplifies the …

Circulating tumor cells: technologies and their clinical potential in cancer metastasis

J Xiao, PR Pohlmann, C Isaacs, BA Weinberg, AR He… - Biomedicines, 2021 - mdpi.com
Circulating tumor cells (CTCs) are single cells or clusters of cells within the circulatory
system of a cancer patient. While most CTCs will perish, a small proportion will proceed to …

Circulating tumor cells: biology and clinical significance

D Lin, L Shen, M Luo, K Zhang, J Li, Q Yang… - Signal transduction and …, 2021 - nature.com
Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and
extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs …

Circulating tumor cells: from bench to bedside

M Balic, A Williams, H Lin, R Datar… - Annual review of …, 2013 - annualreviews.org
Circulating tumor cells (CTCs) represent a surrogate biomarker of hematogenous
metastases. In recent years, their detection has gained increasing interest. There is ample …