Telomere‐Specialized Retroelements in Drosophila: Adaptive Symbionts of the Genome, Neutral, or in Conflict?

DN Markova, SM Christensen, E Betrán - Bioessays, 2020 - Wiley Online Library
Linear chromosomes shorten in every round of replication. In Drosophila, telomere‐
specialized long interspersed retrotransposable elements (LINEs) belonging to the jockey …

Adapting to life at the end of the line: How Drosophila telomeric retrotransposons cope with their job

ML Pardue, PG DeBaryshe - Mobile Genetic Elements, 2011 - Taylor & Francis
Drosophila telomeres are remarkable because they are maintained by telomere-specific
retrotransposons, rather than the enzyme telomerase that maintains telomeres in almost …

Retrotransposons provide an evolutionarily robust non-telomerase mechanism to maintain telomeres

ML Pardue, PG DeBaryshe - Annual review of genetics, 2003 - annualreviews.org
▪ Abstract Telomere molecular biology is far more complex than originally thought.
Understanding biological systems is aided by study of evolutionary variants, and Drosophila …

Chromosoma Focus: Telomere maintenance without telomerase

H Biessmann, JM Mason - Chromosoma, 1997 - Springer
Telomeres are nucleoprotein structures at the ends of eukaryotic chromosomes that perform
a number of vital functions. They allow a cell to distinguish between natural chromosome …

Evolution of species-specific promoter-associated mechanisms for protecting chromosome ends by Drosophila Het-A telomeric transposons

KL Traverse, JA George… - Proceedings of the …, 2010 - National Acad Sciences
The non-LTR retrotransposons forming Drosophila telomeres constitute a robust mechanism
for telomere maintenance, one which has persisted since before separation of the extant …

Drosophila telomeres: an exception providing new insights

JM Mason, RC Frydrychova, H Biessmann - Bioessays, 2008 - Wiley Online Library
Drosophila telomeres comprise DNA sequences that differ dramatically from those of other
eukaryotes. Telomere functions, however, are similar to those found in telomerase‐based …

Telomere maintenance in Drosophila: rapid transposon evolution at chromosome ends

A Villasante, B de Pablos, M Méndez-Lago, JP Abad - Cell Cycle, 2008 - Taylor & Francis
The maintenance of terminal sequences is an important role of the telomere, since it
prevents the loss of internal regions that encode essential genes. In most eukaryotes, this is …

Diversification and collapse of a telomere elongation mechanism

B Saint-Leandre, SC Nguyen, MT Levine - Genome research, 2019 - genome.cshlp.org
In most eukaryotes, telomerase counteracts chromosome erosion by adding repetitive
sequence to terminal ends. Drosophila melanogaster instead relies on specialized …

Retrotransposons at Drosophila telomeres: host domestication of a selfish element for the maintenance of genome integrity

L Zhang, YS Rong - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2012 - Elsevier
Telomere serves two essential functions for the cell. It prevents the recognition of natural
chromosome ends as DNA breaks (the end capping function). It counteracts incomplete end …

[HTML][HTML] Drosophila: retrotransposons making up telomeres

E Casacuberta - Viruses, 2017 - mdpi.com
Drosophila and extant species are the best-studied telomerase exception. In this organism,
telomere elongation is coupled with targeted retrotransposition of Healing Transposon (HeT …