Viral metagenomics next-generation sequencing (mNGS) is increasingly being used to
characterize the human virome. The impact of viral nucleic extraction on virome profiling has …

Background Numerous protocols for viral enrichment and genome amplification have been
created. However, the direct identification of viral genomes from clinical specimens using …

Objectives Sample preparation for high-throughput sequencing (HTS) includes treatment
with various laboratory components, potentially carrying viral nucleic acids, the extent of …

Widespread in public databases, foreign contaminant sequences pose a substantial
obstacle in genomic analyses. Such contamination in viral genome databases is also …

Respiratory virus infections are one of the major causes of acute respiratory disease or
exacerbation of chronic obstructive pulmonary disease (COPD). However, next-generation …

Viral metagenomics is increasingly applied in viral detection and virome characterization.
Different extraction and enrichment techniques may be adopted, however, reports on their …

Background Next generation sequencing (NGS) technology allows laboratories to
investigate virome composition in clinical and environmental samples in a culture …

Insensitivity and technical complexity have impeded the implementation of high-throughput
nucleic acid sequencing in differential diagnosis of viral infections in clinical laboratories …

Current infectious disease molecular tests are largely pathogen specific, requiring test
selection based on the patient's symptoms. For many syndromes caused by a large number …

Human virome, including those of bacteria (bacteriophages) have received an increasing
attention recently, owing to the rapid developments in human microbiome research and the …