The Physiological functions of IKK-selective substrate identification and their critical roles in
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The IκB kinases (IKKs) IKK-α and IKK-β, and the IKK-related kinases TBK1 and IKK-ɛ, have
essential roles in innate immunity through signal-induced activation of NF-κB, IRF3 and …

Protein kinases that regulate the activity of specific transcription factors in response to
extracellular stimuli not only are the subject of intense research but also are being chased …

Cellular responses to stress-like stimuli require the IκB kinase (IKK) signalsome (IKKα, IKKβ,
and NEMO/IKKγ) to activate NF-κB-dependent genes. IKKβ and NEMO/IKKγ are required to …

The transcription factor NF-κB plays a key role in numerous physiological processes such as
inflammation, immunity, cell proliferation or control of cell death. Its activation is tightly …

Inflammation is a beneficial response to insult or injury which plays an important role in
orchestrating the adaptive immune response. The resolution of acute inflammation is an …

Many signaling pathways leading to activation of transcription factors and gene expression
are characterized by phosphorylation events mediated by specific kinases. The transcription …

Transcription factors of the NF-κB family regulate hundreds of genes in the context of
multiple important physiological and pathological processes. NF-κB activation depends on …

The inhibitor of nuclear factor‐κB (IκB) kinase (IKK) complex is the master regulator of the NF‐
κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly …

The IκB kinase (IKK) complex is involved in transcriptional activation by phosphorylating the
inhibitory molecule IκBα, a modification that triggers its subsequent degradation, enabling …