Synthesis, Molecular Docking, and Preliminary Evaluation of 2‐(1, 2, 3‐Triazoyl) benzaldehydes As Multifunctional Agents for the Treatment of Alzheimer's Disease

GP Costa, RSM Baldinotti, MG Fronza… - …, 2020 - Wiley Online Library
We described here our results on the use of thiourea as a ligand in the copper catalysed
azide‐alkyne cycloaddition (CuAAC) of 2‐azidobenzaldehyde with alkynes. Reactions were …

Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer's disease

O Unsal-Tan, TT Küçükkılınç, B Ayazgök, A Balkan… - …, 2019 - pubs.rsc.org
A novel series of 2-pyrazoline derivatives were designed, synthesized, and evaluated for
cholinesterase (ChE) inhibitory, Aβ anti-aggregating and neuroprotective activities. Among …

Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer's disease

M Erdogan, B Kilic, RI Sagkan, F Aksakal… - European Journal of …, 2021 - Elsevier
In this study, four series of compounds with benzoxazolone and benzothiazolone cores were
designed, synthesized and evaluated as multifunctional agents against Alzheimer's disease …

Synthesis and biological evaluation of benzimidazoles/1, 3, 5-triazine-2, 4-diamine hybrid compounds: a new class of multifunctional alzheimer targeting agents

S Karimian, M Shekouhy, S Pirhadi, A Iraji… - New Journal of …, 2022 - pubs.rsc.org
In this study, a series of new benzimidazole/1, 3, 5-triazine-2, 4-diamine hybrid derivatives
(9a–9l) were designed and synthesized. The potential multi-target profiles of these …

Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer's disease

YP Singh, GNVC Tej, A Pandey, K Priya… - European Journal of …, 2020 - Elsevier
In our overall goal to overcome the limitations associated with natural products for the
management of Alzheimer's disease and to develop in-vivo active multifunctional cholinergic …

Design and development of molecular hybrids of 2-pyridylpiperazine and 5-phenyl-1, 3, 4-oxadiazoles as potential multifunctional agents to treat Alzheimer's disease

A Tripathi, PK Choubey, P Sharma, A Seth… - European journal of …, 2019 - Elsevier
The diverse nature of Alzheimer's disease (AD) has prompted researchers to develop multi-
functional agents. Herein, we have designed and synthesized molecular hybrids of 2 …

Design, synthesis, and biological evaluation of some 2-(3-oxo-5, 6-diphenyl-1, 2, 4-triazin-2 (3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease …

DK Waiker, A Verma, TA Gajendra, A Roy… - European Journal of …, 2024 - Elsevier
Inspite of established symptomatic relief drug targets, a multi targeting approach is highly in
demand to cure Alzheimer's disease (AD). Simultaneous inhibition of cholinesterase (ChE) …

Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl) phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease

Z Sang, K Wang, H Wang, H Wang, Q Ma, X Han… - Bioorganic & Medicinal …, 2017 - Elsevier
Abstract A series of 2-acetyl-5-O-(amino-alkyl) phenol derivatives was designed,
synthesized and evaluated as multi-function inhibitors for the treatment of Alzheimer's …

Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents

E Jameel, P Meena, M Maqbool, J Kumar… - European journal of …, 2017 - Elsevier
In our endeavor towards the development of potent multitarget ligands for the treatment of
Alzheimer's disease, a series of triazine-triazolopyrimidine hybrids were designed …

Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer's Disease

P Sharma, A Tripathi, PN Tripathi… - ACS chemical …, 2019 - ACS Publications
Multitargeted hybrids of N-benzylpiperidine and substituted 5-phenyl-1, 3, 4-oxadiazoles
were designed, synthesized, and evaluated against Alzheimer's disease (AD). Tested …