Synthesis, Molecular Docking, and Preliminary Evaluation of 2‐(1, 2, 3‐Triazoyl) benzaldehydes As Multifunctional Agents for the Treatment of Alzheimer's Disease
GP Costa, RSM Baldinotti, MG Fronza… - …, 2020 - Wiley Online Library
We described here our results on the use of thiourea as a ligand in the copper catalysed
azide‐alkyne cycloaddition (CuAAC) of 2‐azidobenzaldehyde with alkynes. Reactions were …
azide‐alkyne cycloaddition (CuAAC) of 2‐azidobenzaldehyde with alkynes. Reactions were …
Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer's disease
O Unsal-Tan, TT Küçükkılınç, B Ayazgök, A Balkan… - …, 2019 - pubs.rsc.org
A novel series of 2-pyrazoline derivatives were designed, synthesized, and evaluated for
cholinesterase (ChE) inhibitory, Aβ anti-aggregating and neuroprotective activities. Among …
cholinesterase (ChE) inhibitory, Aβ anti-aggregating and neuroprotective activities. Among …
Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer's disease
In this study, four series of compounds with benzoxazolone and benzothiazolone cores were
designed, synthesized and evaluated as multifunctional agents against Alzheimer's disease …
designed, synthesized and evaluated as multifunctional agents against Alzheimer's disease …
Synthesis and biological evaluation of benzimidazoles/1, 3, 5-triazine-2, 4-diamine hybrid compounds: a new class of multifunctional alzheimer targeting agents
In this study, a series of new benzimidazole/1, 3, 5-triazine-2, 4-diamine hybrid derivatives
(9a–9l) were designed and synthesized. The potential multi-target profiles of these …
(9a–9l) were designed and synthesized. The potential multi-target profiles of these …
Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer's disease
In our overall goal to overcome the limitations associated with natural products for the
management of Alzheimer's disease and to develop in-vivo active multifunctional cholinergic …
management of Alzheimer's disease and to develop in-vivo active multifunctional cholinergic …
Design and development of molecular hybrids of 2-pyridylpiperazine and 5-phenyl-1, 3, 4-oxadiazoles as potential multifunctional agents to treat Alzheimer's disease
The diverse nature of Alzheimer's disease (AD) has prompted researchers to develop multi-
functional agents. Herein, we have designed and synthesized molecular hybrids of 2 …
functional agents. Herein, we have designed and synthesized molecular hybrids of 2 …
Design, synthesis, and biological evaluation of some 2-(3-oxo-5, 6-diphenyl-1, 2, 4-triazin-2 (3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease …
Inspite of established symptomatic relief drug targets, a multi targeting approach is highly in
demand to cure Alzheimer's disease (AD). Simultaneous inhibition of cholinesterase (ChE) …
demand to cure Alzheimer's disease (AD). Simultaneous inhibition of cholinesterase (ChE) …
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl) phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease
Z Sang, K Wang, H Wang, H Wang, Q Ma, X Han… - Bioorganic & Medicinal …, 2017 - Elsevier
Abstract A series of 2-acetyl-5-O-(amino-alkyl) phenol derivatives was designed,
synthesized and evaluated as multi-function inhibitors for the treatment of Alzheimer's …
synthesized and evaluated as multi-function inhibitors for the treatment of Alzheimer's …
Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents
In our endeavor towards the development of potent multitarget ligands for the treatment of
Alzheimer's disease, a series of triazine-triazolopyrimidine hybrids were designed …
Alzheimer's disease, a series of triazine-triazolopyrimidine hybrids were designed …
Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer's Disease
Multitargeted hybrids of N-benzylpiperidine and substituted 5-phenyl-1, 3, 4-oxadiazoles
were designed, synthesized, and evaluated against Alzheimer's disease (AD). Tested …
were designed, synthesized, and evaluated against Alzheimer's disease (AD). Tested …
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